Results 31 to 40 of about 3,678,963 (228)

In Vitro Primary Screening of a Synthetic Series of Chromenoazoldiones against Trypanosoma cruzi

Proceedings, 2017
Similarities between parasites and cancer have prompted parasitologists to take advantage of several approaches enabled by cancer research to identify antiparasitic agents [1]. [...]
Cristina Fonseca-Berzal, Paula Morales, José A. Escario, Nadine Jagerovic, Alicia Gómez-Barrio   +4 more
doaj   +1 more source

Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands

Frontiers in Chemistry, 2022
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis (CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites belonging to the kinetoplastid order and they constitute an urgent global health problem.
Dinorah Gambino, Lucía Otero
doaj   +1 more source

Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Microbiology Spectrum, 2022
Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite Leishmania species with a wide range of clinical manifestations.
Hannah N. Corman, Jessica N. Ross, Francisco R. Fields, Douglas A. Shoue, Mary Ann McDowell, Shaun W. Lee   +5 more
doaj   +1 more source

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

mBio, 2018
Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B.
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi   +9 more
doaj   +1 more source

Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites

Pharmaceuticals, 2023
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others.
Dimitrios Moianos, Georgia-Myrto Prifti, Maria Makri, Grigoris Zoidis   +3 more
doaj   +1 more source

Analysis of the range of drugs registered in the Russian Federation to control parasitic infections in pigs

Российский паразитологический журнал, 2023
The purpose of the research is the analysis of the range of antiparasitic drugs for pig breeding as registered in the Russian Federation and included in the State Register of Medicinal Products for Veterinary Use.The control of parasitic diseases is an ...
T. V. Gerunov, V. I. Dorozhkin, L. K. Gerunova, M. N. Gonochova, Ya. O. Kryuchek, A. A. Tarasenko, E. A. Chigrinski   +6 more
doaj   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. [PDF]

Chemistry
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Monfret O, Liu D, Louis M, Rebei S, Urban D, Bourdreux Y, Mouray E, Grellier P, Doisneau G, Guianvarc'h D.   +9 more
europepmc   +2 more sources

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Evidence-based indications for ivermectin in parasitic diseases: An integrated approach to context and challenges in Peru

Parasite Epidemiology and Control, 2023
Ivermectin has emerged as a therapeutic option for various parasitic diseases, including strongyloidiasis, scabies, lice infestations, gnathostomiasis, and myiasis.
Virgilio E. Failoc-Rojas, Heber Silva-Díaz, Jorge L. Maguiña, Alfonso J. Rodriguez-Morales, Cristian Díaz-Velez, Moises Apolaya-Segura, Mario J. Valladares-Garrido   +6 more
doaj   +1 more source

Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections

Molecules, 2020
Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control ...
Marcello Casertano, Marialuisa Menna, Caterina Fattorusso, Nicoletta Basilico, Silvia Parapini, Marco Persico, Concetta Imperatore   +6 more
doaj   +1 more source