Results 51 to 60 of about 17,058 (185)
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase. [PDF]
PLoS Neglected Tropical Diseases, 2010 The protozoan parasite Cryptosporidium parvum is responsible for significant disease burden among children in developing countries. In addition Cryptosporidiosis can result in chronic and life-threatening enteritis in AIDS patients, and the currently ...
Lisa Sharling +5 more
doaj +1 more source
Infection risk in rheumatoid arthritis patients treated with biologic and targeted therapies
Rheumatology &Autoimmunity, EarlyView.In this context, infections associated with each biologic and targeted drug are summarized to inform the stratification of RA patients, including the characteristics of the susceptible patients and their concomitant therapy. We aim to provide a benefit‐risk analysis for clinical decision, and vital indications for the prevention of highly correlated ...
Lujing Wang, Jieshi Lin, Jie Qian
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background Antimicrobial resistance (AMR) is a critical global health issue, with antimicrobial use (AMU) in veterinary medicine playing a relevant role in its emergence. This study aimed to evaluate the knowledge, attitudes and practices of Austrian veterinarians regarding AMU and AMR.
Clair L. Firth +4 more
wiley +1 more source
Sensory profile of cats with potential pain‐related diabetic neuropathy
Veterinary Record, EarlyView.Abstract Background Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Hélène L. M. Ruel +4 more
wiley +1 more source
Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products
Memorias do Instituto Oswaldo Cruz, 2015 This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled.
Emeline Houël +6 more
doaj +1 more source
Treatment of discospondylitis in dogs: A systematic review
Veterinary Record, EarlyView.Abstract Background Both medical and surgical techniques have been reported to manage canine discospondylitis, although data on clinical effectiveness and long‐term prognosis remain limited. Methods A systematic review of studies on treatment approaches, follow‐up data and investigation methods was conducted.
Vasileios Ioannis Vallios +4 more
wiley +1 more source
The polysaccharide Pullulan improves the initial steps of allergen‐specific immunotherapy in dogs
Veterinary Record, EarlyView.Abstract Background Allergen‐specific immunotherapy (AIT) is the only aetiological treatment for canine atopic dermatitis (CAD). Pullulan, a polysaccharide with immunomodulatory properties, may enhance AIT outcomes when combined with allergens such as recombinant Dermatophagoides farinae 2 (Der f 2).
Franco Martini +3 more
wiley +1 more source
Demodex Infestation in Patients With Atopic Dermatitis Treated With Dupilumab: A Case–Control Study
The Journal of Dermatology, EarlyView.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease in which dupilumab, an interleukin‐4 receptor alpha antagonist, has become a cornerstone therapy for moderate‐to‐severe disease. However, persistent facial and neck erythema and related symptoms have been increasingly reported during dupilumab treatment, and the underlying ...
Pinar Dursun +2 more
wiley +1 more source