Results 41 to 50 of about 3,678,963 (228)

Discovery of 1,3,4-Oxadiazole Derivatives as Broad-Spectrum Antiparasitic Agents.

ACS Infectious Diseases
Vector-borne parasitic diseases (VBPDs) pose a significant threat to public health on a global scale. Collectively, Human African Trypanosomiasis (HAT), Leishmaniasis, and Malaria threaten millions of people, particularly in developing countries. Climate
Alexandra Ioana Corfu, N. Santarém, Sara Luelmo, Gaia Mazza, Alessandro Greco, A. Altomare, G. Ferrario, Giulia Nasta, Oliver Keminer, G. Aldini, L. Tamborini, N. Basilico, S. Parapini, Sheraz Gul, A. Cordeiro-da-Silva, P. Conti, Chiara Borsari   +16 more
semanticscholar   +1 more source

Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni

Pharmaceuticals, 2021
The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, a disease of great global public health significance. Praziquantel is the only drug available to treat schistosomiasis and there is an urgent demand for new ...
R. Porto, Ana C. Mengarda, Rayssa A. Cajás, M. Salvadori, Fernanda S. Teixeira, D. Arcanjo, A. Siyadatpanah, M. L. Pereira, P. Wilairatana, J. Moraes   +9 more
semanticscholar   +1 more source

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.

PLoS Neglected Tropical Diseases, 2017
Protozoan parasites infect and kill millions of people worldwide every year, particularly in developing countries where access to clean fresh water is limited.
Bharat Bashyal, Linfeng Li, Trpta Bains, Anjan Debnath, Daniel V LaBarbera   +4 more
doaj   +1 more source

Synthesis and Antiplasmodial Activity of Novel Bioinspired Imidazolidinedione Derivatives

Biomolecules, 2020
Malaria is an enormous threat to public health, due to the emergence of Plasmodium falciparum resistance to widely-used antimalarials, such as chloroquine (CQ).
Anna Jaromin, Anna Czopek, Silvia Parapini, Nicoletta Basilico, Ernest Misiak, Jerzy Gubernator, Agnieszka Zagórska   +6 more
doaj   +1 more source

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Drugs and Drug Candidates
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
T. Mohapatra, R. Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
semanticscholar   +1 more source

Anti-BioEn: An advanced framework for accurate bioactive agent classification based on hybrid models and graph feature encoding method [PDF]

BIO Web of Conferences
Bioactive agents are compounds that have an influence on human beings, organs, or tissues. These agents, which might be found in both natural and synthetic chemicals, are able to interact with biological systems and produce a variety of therapeutic or ...
Shaon Shazzad Hossain, Sultan Fahim, Karim Tasmin, Akter Shapna   +3 more
doaj   +1 more source

A 20 Years Retrospective Descriptive Study of Human Cystic Echinococcosis and the Role of Albendazole Concurrent with Surgical Treatment: 2001-2021

Iranian Journal of Parasitology, 2023
Background: Hydatid cyst, caused by the larvae of Echinococcus granulosus, is one of the most severe cestode infections occurring in Iran. The liver is the most commonly involved organ.
Setareh Mahmoodi, Manoochehr Ebrahimian, Seyed Hadi Mirhashemi, Mohsen Soori, Fariborz Rashnoo, Bahador Oshidari, Rouzbeh Shadidi Asil, Amir Zamani, Esmaeil Hajinasrollah   +8 more
doaj   +1 more source

Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents

Medicinal Chemistry Research
Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania. The corresponding diseases have afflicted humans for centuries.
Koketso J Setshedi, Richard M. Beteck, Kayhan Ilbeigi, Dorien Mabille, G. Caljon, L. Legoabe   +5 more
semanticscholar   +1 more source

Organometallics in Medicinal Chemistry: Antiparasitic Agents

Journal of the Brazilian Chemical Society
Neglected tropical diseases (NTDs) encompass a diverse group of 20 medical conditions triggered by various pathogens, including viruses, bacteria, protozoa, and parasitic worms.
D. Gambino
semanticscholar   +1 more source

Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use

Current Research in Parasitology and Vector-Borne Diseases
Many antiparasitic drugs have become obsolete and ineffective in treating parasitic diseases. This ineffectiveness arises from parasite drug resistance, high toxicity, and low drug efficacy.
Pichet Ruenchit
doaj   +1 more source