Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Pramipexole protective effect on rotenone induced neurotoxicity in mice [PDF]
Introduction: Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic
Abdelaziz A. Ghanem+6 more
core +1 more source
The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy [PDF]
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons. Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD.
Cheong, Siew L+4 more
core +1 more source
Metoclopramide Neurological Side Effects Screening; A Pharmacovigilence Study in Romanian Community Pharmacies [PDF]
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics.
Junghină, Adrian+4 more
core +3 more sources
Therapy concordance and drug adherence in Parkinson's disease [PDF]
Chapter 1 gives an overview of the relevance of studying therapy adherence in Parkinson’s disease. Chapter 2 examines drug induced neurological syndromes and considers the validity of patients’ concerns about taking prescribed medications.
Grosset, Katherine Anne
core +1 more source
Cyclopentenyl ethylamines active on CNS [PDF]
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic
Dimich, P.M.+6 more
core
On Networks with Active and Passive Agents [PDF]
We introduce an active-passive networked multiagent system framework, which consists of agents subject to exogenous inputs (active agents) and agents without any inputs (passive agents), and analyze its convergence using Lyapunov stability.
arxiv
Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems [PDF]
Neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease(AD), are a group of pathologies characterized by a progressive and specific loss of certain brain cell populations.
Baldassarre, Leonardo+4 more
core +3 more sources
AgentFormer: Agent-Aware Transformers for Socio-Temporal Multi-Agent Forecasting [PDF]
Predicting accurate future trajectories of multiple agents is essential for autonomous systems, but is challenging due to the complex agent interaction and the uncertainty in each agent's future behavior. Forecasting multi-agent trajectories requires modeling two key dimensions: (1) time dimension, where we model the influence of past agent states over
arxiv
Dopamine Agonists and their risk to induce psychotic episodes in Parkinson's disease: a case-control study [PDF]
Background Psychosis is rare in untreated patients with Parkinson's disease (PD) but the prevalence rises to 40% during dopaminergic treatment. So far, no systematic comparison of the psychogenic potential of different dopaminergic drugs had been ...
A Boyd+48 more
core +3 more sources