Evidence-based guidelines for the antipsychotic drugs: Schizophrenia
Psychiatry and Clinical Psychopharmacology, 2021 Antipsychotic medications, as the standard pharmacologic treatment of schizophrenia, are used to decrease symptoms and to increase functioning. The currently available antipsychotics are all significantly efficacious for positive symptoms.
Özcan Uzun
doaj
Health-related quality of life and depression among participants in the Sjögren's International Collaborative Clinical Alliance registry. [PDF]
, 2017 ObjectiveTo examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS.MethodsCross-sectional study of participants in the Sjögren's ...
Chou, Annie +5 more
core +1 more source
The use of anticholinergic antiparkinson agents in Norway: Epidemiology, toxicology and clinical implications [PDF]
, 2010 This thesis is based on two fundamental questions: Which patients are currently using anticholinergic antiparkinson drugs? Does it matter which anticholinergic antiparkinson drug they are using?
Gjerden, Pål
core +1 more source
N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]
, 2014 On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Agbaba, D. +13 more
core +3 more sources
Changing trends in drug overdose mortality in Spain, 2001–2022
Addiction, Volume 121, Issue 2, Page 261-272, February 2026.Abstract Aim To measure the evolution of drug overdose mortality in Spain between 2001 and 2022. Design, Setting, Participants A repeated cross‐sectional observational study using nationwide mortality data from Spain, 2001–2022, among individuals aged 15–64 years.
Florencia Giné +6 more
wiley +1 more source
The Treatment of Hallucinations in Schizophrenia Spectrum Disorders [PDF]
, 2012 This article reviews the treatment of hallucinations in schizophrenia. The first treatment option for hallucinations in schizophrenia is antipsychotic medication, which can induce a rapid decrease in severity.
Agid +46 more
core +4 more sources
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
ChemistrySelect, Volume 11, Issue 2, 15 January 2026.Three phenanthrene alkaloids from Guatteria olivacea were studied by DFT, docking, MD, and cytotoxicity assays. All compounds showed stable binding to DNA–topoisomerase II and human serum albumin. Atherosperminine exhibited cytotoxic activity against four cancer cell lines, supporting its potential as a topoisomerase II inhibitor and anticancer ...
Renyer A. Costa +8 more
wiley +1 more source
Cyclopentenyl ethylamines active on CNS [PDF]
, 1992 Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic
Dimich, P.M. +6 more
core
Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review
BioMed Research International, Volume 2026, Issue 1, 2026.All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh +3 more
wiley +1 more source