Results 11 to 20 of about 2,700 (139)

Anticonvulsant Activity of Antiparkinsonism Agents

Experimental Biology and Medicine, 1968
SummaryThe anticonvulsant activity of synthetic antiparkinsonism agents has been studied in mice with experimental seizures and in children with myoclonic spasms refractory to conventional medications. Procyclidine and trihexyphenidyl protected mice from maximal electroshock seizures.
J G, Millichap, G L, Pitchford, M G, Millichap   +2 more
openaire   +2 more sources

Evidence-based guidelines for the antipsychotic drugs: Schizophrenia

Psychiatry and Clinical Psychopharmacology, 2021
Antipsychotic medications, as the standard pharmacologic treatment of schizophrenia, are used to decrease symptoms and to increase functioning. The currently available antipsychotics are all significantly efficacious for positive symptoms.
Özcan Uzun
doaj  

Sustained Release Antiparkinson Agents: Controlled Release Levodopa [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1992
ABSTRACT:The rationale for sustained release oral levodopa preparations is to deliver levodopa in the areas of maximal intestinal absorption in a slow and predictable way, leading to stable plasma levodopa levels and brain dopamine levels, therefore resulting in a lengthened duration of action.
S, Gauthier, D, Amyot
openaire   +2 more sources

Changing trends in drug overdose mortality in Spain, 2001–2022

Addiction, Volume 121, Issue 2, Page 261-272, February 2026.
Abstract Aim To measure the evolution of drug overdose mortality in Spain between 2001 and 2022. Design, Setting, Participants A repeated cross‐sectional observational study using nationwide mortality data from Spain, 2001–2022, among individuals aged 15–64 years.
Florencia Giné, Marta Donat, Juan Miguel Guerras, Gregorio Barrio, María José Belza, Julieta Politi, Enrique Regidor   +6 more
wiley   +1 more source

Phenanthrene Alkaloids From Guatteria Olivacea as Topoisomerase II Inhibitors: Theoretical Insights and Cytotoxic Evaluation

ChemistrySelect, Volume 11, Issue 2, 15 January 2026.
Three phenanthrene alkaloids from Guatteria olivacea were studied by DFT, docking, MD, and cytotoxicity assays. All compounds showed stable binding to DNA–topoisomerase II and human serum albumin. Atherosperminine exhibited cytotoxic activity against four cancer cell lines, supporting its potential as a topoisomerase II inhibitor and anticancer ...
Renyer A. Costa, Victor L. Tananta, Ianni de O. Corrêa, Jamelah S. Al‐Otaibi, Y. Sheena Mary, Milena Botelho P. Soares, Daniel P. Bezzera, Morgana de S. Araújo, Emmanoel V. Costa   +8 more
wiley   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Association between Parkinson’s disease and cardiovascular disease mortality: a prospective population-based study from NHANES

Lipids in Health and Disease
Background and aim Conflicting results have been reported on the association between Parkinson's disease (PD) and cardiovascular disease (CVD) mortality in different populations.
Li Ke, Lei Zhao, Wenli Xing, Qiaosheng Tang   +3 more
doaj   +1 more source

Social Determinants of Health and Their Association With Parkinson′s Disease Prevalence in US Adults: Insights From NHANES 2001–2020

Behavioural Neurology, Volume 2026, Issue 1, 2026.
Background Social determinants of health (SDoH) have not been comprehensively studied in relation to Parkinson′s disease (PD), although they are well known to be associated with other chronic diseases. Here we assessed the relationship of a multidimensional, comprehensive measure of SDoH with the prevalence of PD in US adults.
Jinping Fang, Detao Meng, Boyan Fang, Karsten Witt   +3 more
wiley   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

Oral Health in Individuals with Severe Mental Illness on Second‐Generation Antipsychotics—A Scoping Review

Journal of Oral Pathology &Medicine, Volume 54, Issue 6, Page 401-412, July 2025.
ABSTRACT Introduction There has been a significant increase in antipsychotic usage, particularly belonging to second‐generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear.
Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar   +7 more
wiley   +1 more source