Results 1 to 10 of about 53,102 (149)
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Blood Reviews, 1997
Antiplatelet drugs are used in a wide range of disorders, either as sole agents or as adjuncts to other therapies. Aspirin has been shown to be clinically effective in a number of ischaemic conditions and has been in use for many years. The newer agents, ticlopidine and clopidogrel (which are thought to inhibit ADP-mediated platelet reactions) are also
J E, Joseph, S J, Machin
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Antiplatelet drugs are used in a wide range of disorders, either as sole agents or as adjuncts to other therapies. Aspirin has been shown to be clinically effective in a number of ischaemic conditions and has been in use for many years. The newer agents, ticlopidine and clopidogrel (which are thought to inhibit ADP-mediated platelet reactions) are also
J E, Joseph, S J, Machin
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Clinical pharmacology of antiplatelet drugs
Expert Review of Clinical Pharmacology, 2022Platelets play a key role in arterial thrombosis and antiplatelet therapy is pivotal in the treatment of cardiovascular disease. Current antiplatelet drugs target different pathways of platelet activation and show specific pharmacodynamic and pharmacokinetic characteristics, implicating clinically relevant drug-drug interactions.This article reviews ...
Georg Gelbenegger, Bernd Jilma
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Antiplatelet drugs in thromboembolism
Postgraduate Medicine, 1979Evidence is mounting that three drugs that inhibit platelet function--aspirin, dipyridamole, and sulfinpyrazine--have an antithrombotic effect in humans. Particularly in men, aspirin is beneficial in controlling transient ischemic attacks and stroke, and there is evidence that it may be effective in preventing thrombotic and embolic complication of hip
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Antithrombotic and Antiplatelet Drug Toxicity
Critical Care Clinics, 2021Anticoagulant and antiplatelet drugs target a specific portion of the coagulation cascade or the platelet activation and aggregation pathway. The primary toxicity associated with these agents is hemorrhage. Understanding the pharmacology of these drugs allows the treating clinician to choose the correct antidotal therapy. Reversal agents exist for some
David B, Liss, Michael E, Mullins
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Drugs, 1995
Antiplatelet therapy has become a useful means of preventing acute thromboembolic artery occlusions in cardiovascular diseases. The rationale for this is an enhanced activity of circulating platelets and release of platelet-derived vasoactive mediators, probably due to endothelial dysfunction. This review discusses the current status of 4 major classes
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Antiplatelet therapy has become a useful means of preventing acute thromboembolic artery occlusions in cardiovascular diseases. The rationale for this is an enhanced activity of circulating platelets and release of platelet-derived vasoactive mediators, probably due to endothelial dysfunction. This review discusses the current status of 4 major classes
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The genetics of antiplatelet drug resistance
Clinical Genetics, 2008Platelets have a central role in the development of arterial thrombosis and subsequent cardiovascular events. An appreciation of this complex process has made antiplatelet therapy the cornerstone of cardiovascular disease management. However, numerous patients will experience a recurrent atherothrombotic vascular event despite adequate antiplatelet ...
Fehér, G. +5 more
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Antimicrobial effects of antiplatelet drugs and antimicrobial / antiplatelet drug combinations
2021Duale Antiplättchen-Therapie (DAPT), bestehend aus einem P2Y12-Rezeptor-Inhibitor und Acetylsalicylsäure (Aspirin), stellt den Eckpfeiler der pharmakologischen Behandlung des akuten Koronarsyndroms (ACS) dar. Gegenwärtig gibt es eine wachsende Zahl von Belegen für die antimikrobielle Aktivität von Ticagrelor, einem P2Y12-Inhibitor, aber es ergaben sich
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Platelet Resistance to Antiplatelet Drugs
Recent Patents on Cardiovascular Drug Discovery, 2009In patients with cardiovascular diseases, platelet aggregation plays an important role in development of cardiovascular events and hence its inhibition is important in prevention and treatment of these events. Antiplatelet therapy is the cornerstone of treatment for patients with acute coronary syndrome and in those who undergo percutaneous coronary ...
Ashwani, Kumar, John, Kao
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Drugs, 1979
Because platelets are so important in thrombus formation, drugs which inhibit platelet function (the 'antiplatelet drugs') have considerable potential as antithrombotic agents. Among the antiplatelet drugs, only aspirin, sulphinpyrazone, dipyridamole, hydroxychloroquine, and clofibrate have had wide clinical trial.
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Because platelets are so important in thrombus formation, drugs which inhibit platelet function (the 'antiplatelet drugs') have considerable potential as antithrombotic agents. Among the antiplatelet drugs, only aspirin, sulphinpyrazone, dipyridamole, hydroxychloroquine, and clofibrate have had wide clinical trial.
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Nihon rinsho. Japanese journal of clinical medicine, 2014
Antiplatelet therapy is widely used with proven benefit for the prevention of further ischemic complications in patients with coronary heart disease and stroke. Treatment guidelines for acute coronary syndrome and percutaneous coronary intervention now recommend the use of oral antiplatelet agents including clopidogrel in combination with aspirin (dual
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Antiplatelet therapy is widely used with proven benefit for the prevention of further ischemic complications in patients with coronary heart disease and stroke. Treatment guidelines for acute coronary syndrome and percutaneous coronary intervention now recommend the use of oral antiplatelet agents including clopidogrel in combination with aspirin (dual
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