Results 261 to 270 of about 5,245,251 (341)

Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma

Transfusion, EarlyView.
Abstract Background Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma‐induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need
Niruktha Raghavan, Mira Patel, Bryan A. Cotton, Julia Coleman, Donald Jenkins   +4 more
wiley   +1 more source

Preclinical Efficacy of a Hemostatic Agent in Overcoming Dual Antiplatelet Therapy. [PDF]

JACC Basic Transl Sci
Efimenko E, Zhao H, Moskowitz K, Smith C, Pyo R, Diacovo TG.   +5 more
europepmc   +1 more source

Transfusion‐related alpha‐gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation

Transfusion, EarlyView.
Abstract Background Transfusion‐related alpha‐gal syndrome (TRAGS) has recently been proposed as a cause of allergic transfusion reactions (ATRs) in which alpha‐gal‐specific IgE in sensitized group O (or potentially group A) recipients reacts with epitopes on group B or AB plasma‐containing components.
Mackenzie Foster, Miriam Brown, Angela Mueller, Toufik Tahiri, Kaycie Atchison, Deva Sharma, Cosby A. Stone Jr., Jonathan Tucci, Garrett S. Booth, Jeremy W. Jacobs   +9 more
wiley   +1 more source

Balancing Bleeding and Ischemic Risk: Dual Antiplatelet Therapy in a 90-Year-Old Man With Myocardial Infarction and Gastrointestinal Bleeding. [PDF]

Am J Case Rep
Battenberg A, Bell MR, Singh M, Jaffe AS, Tweet MS.   +4 more
europepmc   +1 more source

Prothrombin complex concentrate for oral factor Xa inhibitor reversal prior to urgent invasive procedures

Transfusion, EarlyView.
Abstract Background Oral factor Xa (FXa) inhibitors are anticoagulants with no approved reversal agent for use before urgent invasive procedures. Four‐factor prothrombin complex concentrate (4F‐PCC) is used off‐label for this despite limited evidence regarding its effectiveness and safety.
Mohammad Shamiea, Alex Osnis, Awan Kashoua, Orli Avnery, Gilad Itchaki, Shuli Isman, Tali Tohami, Osnat Jarchowsky‐Dolberg, Martin Ellis   +8 more
wiley   +1 more source

Previous Antiplatelet Therapy on Ticagrelor-Aspirin and Clopidogrel-Aspirin Efficacy in Intracranial Artery Stenosis. [PDF]

J Stroke
Xu Q, Lyu Z, Zhang Y, Xia X, Tian X, Zhang X, Wang Y, Meng X, Wang A.   +8 more
europepmc   +1 more source

Platelet clotting defects in severe trauma identified by a whole blood microfluidic assay

Transfusion, EarlyView.
Abstract Background Hemorrhage is the leading cause of preventable death in severe trauma, with primary hemostasis relying on platelet‐rich clot formation under high shear flow. This study quantifies the incidence, severity, and heterogeneity of platelet dysfunction in Level I trauma patients.
Gian Rivera Crespo, Jack Killinger, Christopher Bresette, Susan M. Shea, David Ku   +4 more
wiley   +1 more source

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials. [PDF]

PLoS Med
Navarese EP, Gurbel P, Tantry U, Talanas G, Grzelakowska K, Umińska J, Jeong YH, Bliden K, Khan SU, Kubica J, Henry TD, Farkouh ME, Kereiakes DJ.   +12 more
europepmc   +1 more source

Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Transfusion, EarlyView.
Abstract Background The precise thresholds at which admission fibrinogen predicts mortality and organ dysfunction in trauma patients are unknown. Study Design and Methods Retrospective study at a single trauma center. Inclusion criteria: 18–89 years, traumatic mechanism, transported from scene, and fibrinogen obtained within 30‐min of arrival ...
Justin Richards, Joseph Kufera, Mary Burgoyne, Deborah Stein, Rosemary Kozar   +4 more
wiley   +1 more source

Prior Dual Antiplatelet Therapy and Mortality After Intracerebral Hemorrhage: A Danish Nationwide Cohort Study. [PDF]

J Am Heart Assoc
Ovesen C, García Rodríguez LA, Hallas J, Storm C, Hald SM, Möller S, Selim M, Gaist D.   +7 more
europepmc   +1 more source