Results 161 to 170 of about 90,202 (264)

Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther, Elsa Peev, Annika Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiss, Corinna C. Pleintinger, Emmanuel Asu Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, Irmela Jeremias, Franziska R. Traube, Thomas Carell   +17 more
wiley   +2 more sources

Cryptocaryone Exhibits ROS/MAPK-Dependent Antiproliferative and Apoptosis-Inducing Effects on Triple-Negative Breast Cancer Cells and Proof-of-Concept Breast Cancer Mouse Model. [PDF]

Drug Dev Res
Chuang YT, Liu W, Chien TM, Farooqi AA, Chang HS, Shiau JP, Chang HW.   +6 more
europepmc   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors. [PDF]

ACS Med Chem Lett
Li S, Yang X, Yin W, Zhang W, Li Z, Hu J, Li Y.   +6 more
europepmc   +1 more source

Exploring the Chemical Space Around Protoflavonoids: Synthesis and Antitumor Activity of Protochalcones

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Natural and synthetic protoflavonoids offer potent anticancer properties, but their chemical space remains largely unexplored. This study details the synthesis of eleven p‐hydroxydienone derivatives from chalcone precursors. We evaluated their antiproliferative effects across four human gynecological cancer cell lines.
Tímea Gonda, Kornél Szőri, Ahmed Dhahir Latif, Norbert Kúsz, János Soltész, István Zupkó, Erzsébet Mernyák, Attila Hunyadi   +7 more
wiley   +1 more source

Tetrazolylidene-Stabilized Gold(I) Complexes: Synthesis and Evaluation of Anticancer Activity <i>In Vitro</i>. [PDF]

Inorg Chem
Stifel S, Schmidt C, Richter LF, Pöthig A, Casini A, Kühn FE.   +5 more
europepmc   +1 more source

The Tumor Cell Proliferation Inhibitory Activity of the Human Herpes Virus Type 6 U94 Protein Relies on a Stable Tridimensional Conformation. [PDF]

Microorganisms
Bertelli A, Uggeri M, Filippini F, Duheric M, Caccuri F, Caruso A.   +5 more
europepmc   +1 more source

Molecular Insights into the Interaction Between Metformin and Caffeine: The Time-Dependent Antagonism and Modulation of p53 Signaling in Cancer Cells. [PDF]

Molecules
Zeljković V, Bogavac M, Dekić M, Minić S, Mahmutović E, Kunkin V, Marković Z, Karaman M.   +7 more
europepmc   +1 more source