Results 161 to 170 of about 136,781 (306)

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Pd-catalyzed, oxidant-promoted, chelation-assisted, regioselective direct <i>ortho</i>-nitration of 1-aryl-1<i>H</i>-indazoles <i>via</i> C-H bond activation: direct access to novel indazole-based antiproliferative agents. [PDF]

RSC Adv
Sen J, Shivani, Kumar P, Datusalia AK, Chaudhary S.   +4 more
europepmc   +1 more source

Sulfur‐ and Selenium‐Decorated Coumarins: Synthetic Strategies Involving Cyclization and Late‐Stage Functionalization

The Chemical Record, EarlyView.
Two decades of synthetic strategies for sulfur‐, selenium‐decorated coumarins are critically surveyed through 44 literature reports, with particular emphasis on derivatives functionalized at the C‐3 and C‐4 positions. This review reports the direct construction of the coumarin framework through cyclization processes and late‐stage functionalization of ...
Bruna R. Schneider, Laura D. de Avila, Mauricio C. D. F. Xavier, Alex F. C. Flores, Liane K. Soares, Gabriel P. da Costa, Angelita M. Barcellos   +6 more
wiley   +1 more source

In Vitro and In Vivo Immunomodulatory and Protective Effects of Leukemia Inhibitory Factor‐Engineered Mesenchymal Stromal Cells in Experimental Endotoxemia

Microbiology and Immunology, EarlyView.
ABSTRACT Sepsis is a life‐threatening condition characterized by dysregulated systemic inflammation and high mortality rates. Mesenchymal stem/stromal cells (MSCs) have emerged as promising immunomodulatory agents; however, genetic engineering strategies can enhance their therapeutic efficacy.
Alana Costa de Oliveira, Diego de Carvalho Carneiro, Luiza Carolina França Opretzka, Breno Cardim Barreto, Dahara Keyse Carvalho Silva, Girlaine Café Santos, Cássio Santana Meira, Milena Botelho Pereira Soares   +7 more
wiley   +1 more source

Comparative Metabolomics Identifies Diterpene-Rich Marine Macroalgae with Potent Antiproliferative Activity Against Colorectal Cancer Cells. [PDF]

Mar Drugs
García-Cervantes AM, Chileh-Chelh T, López-Ruiz R, Gallardo-Rodríguez JJ, Guil-Guerrero JL.   +4 more
europepmc   +1 more source

Guanosine-Induced Antiproliferative Effects Are Modulated by GPCR Expression in Human Glioma and Melanoma Cell Lines.

, 2012
Guanosine-Induced Antiproliferative Effects Are Modulated by GPCR Expression in Human Glioma and Melanoma Cell ...
Giuliani, P, Condorelli, DF, Garozzo, R, Caciagli, F, DI LIBERTO, Valentina, BELLUARDO, Natale   +5 more
core  

Snake Gut Microbiota as a Source of Anti‐Inflammatory Probiotics: Isolation and Functional Characterization of Two Novel Strains

Integrative Zoology, EarlyView.
This study assessed the probiotic potential of intestinal microbiomes from five snake species using metagenomics and in vitro isolation, identifying two promising strains (Lactobacillus johnsonii DA0116 and Limosilactobacillus reuteri DA0218) through comprehensive screening.
Xuena Kang, Lan Hu, Jiarong Song, Zhenjie Zhang, Yi Li, Qingqing Zhang, Cuiling Luo, Yu Pang, Peng Guo, Bisong Yue, Ping Li, Zhenxin Fan   +11 more
wiley   +1 more source

Quinazolinone-diarylpyrazole hybrids as dual EGFR/COX-2 inhibitors: antiproliferative, mechanistic, and <i>in silico</i> studies. [PDF]

RSC Adv
Alkhammash A, Saleem BAA, Oudah KH, Ahmed M, Abass KS, Farhan SM, Zaki MEA, Gomha SM.   +7 more
europepmc   +1 more source

Proliferative vitreoretinopathy: An integrative, multi‐pathway perspective on pathogenesis and therapy

Acta Ophthalmologica, EarlyView.
Abstract Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment‐restricted mechanisms do not fully explain the heterogeneity, biomechanical behaviour and clinical ...
Koen A. van Overdam, J. Sebag
wiley   +1 more source