Results 181 to 190 of about 136,781 (306)

Integrated computational and experimental identification of a novel ML-IAP-targeting peptide with antiproliferative activity in leukaemia cells. [PDF]

J Enzyme Inhib Med Chem
Wan Y, Hu Y, Hong Y, Zhang Y, Hu N, Yao J, Fu W, Yang X, Yue J.   +8 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Machine Learning-Guided Virtual Screening Identifies a Novel MELK-Targeted Antiproliferative Lead Compound with G2/M Arrest Activity in Triple-Negative Breast Cancer and Lung Adenocarcinoma Cells. [PDF]

Cancers (Basel)
Cao W, Jiang B, Chi X, Li W, Yang H, Li X, Zhao Y, Zhang X, Meng R, Cang Y, Du G, Wang J.   +11 more
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Correction: Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax. [PDF]

J Exp Clin Cancer Res
Gaur T, Poddutoori R, Khare L, Bagal B, Rashmi S, Patkar N, Tembhare P, Pg S, Shetty D, Dutt A, Zhang Q, Konopleva M, Platzbeckar U, Gupta S, Samajdar S, Ramchandra M, Khattry N, Hasan SK.   +17 more
europepmc   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Retraction Note: Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora. [PDF]

Microb Cell Fact
Eldeghidy A, Abdel-Fattah G, El-Sayed ASA, Abdel-Fattah GG.   +3 more
europepmc   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Structure-guided discovery of novel ERα-binding peptides with in vitro antiproliferative activity. [PDF]

J Enzyme Inhib Med Chem
Guo T, Zhang Y, Yang S, Yang L, Chen Q, Wang Y, Dou R, Yuan D.   +7 more
europepmc   +1 more source

Stress‐specific metabolic and physiological responses to drought and waterlogging in Allium cepa L. and Allium × cornutum Clementi ex Vis.

Plant Biology, EarlyView.
Drought and waterlogging induce distinct species‐specific metabolic, physiological and transcriptional responses in Allium cepa and Allium × cornutum. Abstract Increasing variability in water availability, caused by changing climatic conditions, is a major constraint for onion production.
Ž. Fredotović, B. Soldo, B. Urlić, K. Radovani, E. Vuko, J. Puizina   +5 more
wiley   +1 more source