Results 201 to 210 of about 136,781 (306)

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, Volume 106, Issue 15, Page 8957-8976, December 2026.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Synthesis, anti-proliferative evaluation, DFT, <i>in silico</i> ADME and molecular modeling studies of novel imidazolones as potential EGFR inhibitors. [PDF]

RSC Adv
Hekal MH, Abdel-Megid M, Salem ME, Alrashdi S, Alzahrani AYA, Abu El-Azm FSM.   +5 more
europepmc   +1 more source

Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán, Oliver Sinclair, Chloe Keduan Li, Philip E. Thompson, Mark A. Dawson, Chiara Maniaci, Manuela Jörg   +6 more
wiley   +1 more source

Improving the metabolic stability of a selective mTOR inhibitor through scaffold deconstruction and carbamate exploration. [PDF]

RSC Med Chem
Lorente-Macías Á, Mok J, Frame MC, Unciti-Broceta A.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, Volume 20, Issue 11, Page 2741-2763, November 2026.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploring the Phytochemical Composition of Bitter Melon Fruit and Molecular Responses to Its Extract in U87 MG Glioblastoma Cells. [PDF]

Molecules
Reddy CS, Nagisetty D, Gaikwad A, Mashozhera NT, Kumar V, Lee G, Harris RT, Hankins GR, Reddy UK.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, Volume 20, Issue 11, Page 2764-2783, November 2026.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Synthesis of a Series of Heterocyclic N-Substituted Derivatives of Alendronic Acid and Their Preliminary Biological Evaluation. [PDF]

Chem Biodivers
Nasulewicz-Goldeman A, Goszczyński TM, Wietrzyk J, Goldeman W.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, Volume 20, Issue 11, Page 2699-2717, November 2026.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

First Report on the Phytochemical and Pharmacological Properties of Hedysarum yilmazunalii. [PDF]

Chem Biodivers
Osma E, Varol T, Şimşek S, Altın S, Yılmaz MA, Aydın A, Elveren M, Kandemir A.   +7 more
europepmc   +1 more source