Results 221 to 230 of about 186,437 (313)

Antiproliferative and Pro-apoptotic Effects of Sesquiterpene Lactones from <i>Schkuhria pinnata</i> in THP‑1 Leukemia Cells. [PDF]

ACS Omega
Jankovská D, Kauerová T, Kunovská R, Čudová M, Melicharová J, Vogliardi S, Šmejkal K, Kollár P, Malaník M.   +8 more
europepmc   +1 more source

Artesunate Induces G0/G1 Phase Arrest in Tumor Cells and Associates With Cyclin‐Dependent Kinase 4 (CDK4)

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death worldwide. Cyclin‐dependent kinase 4 (CDK4) is a well‐validated oncogenic driver in NSCLC, yet current CDK4 inhibitors—predominantly based on the aminopyrimidine scaffold—are limited by structural homogeneity and the rapid emergence of acquired ...
Xinyu Chi, Qicong Chen, Gang Wang, Honglin Luo, Shenhong Qu, Xiaosu Zou   +5 more
wiley   +1 more source

Design, Synthesis and Evaluation of Anticancer Potential of Novel Pyrrolopyrazines Against Glioblastoma: Mechanistic Details and In Vivo Safety Analysis. [PDF]

Arch Pharm (Weinheim)
Usta A, Kuzu B, Tan-Uygun M, Yüksek V, Edip Akyol M, Menges N.   +5 more
europepmc   +1 more source

Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Introduction Cervical cancer remains a leading cause of cancer‐related mortality among women globally, particularly in low‐ and middle‐income countries. Cisplatin, a standard chemotherapeutic agent, is limited by severe toxicities and chemoresistance. This study aimed to assess the effects of cisplatin in combination with phytocannabinoids, Δ9‐
S. P. Mathibela, M. T. Lebelo, V. Steenkamp   +2 more
wiley   +1 more source

Effects of irisin on inflammatory and apoptotic markers in the Caco-2 colon cancer cell line. [PDF]

BMC Mol Cell Biol
Ozturk EZ, Bakan E, Baygutalp NK, Bayraktutan Z.   +3 more
europepmc   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

Development, anti-proliferative activity, multi-target kinase inhibition against CHK1, PIM1, and CDK-2, and computational insights of new thiazole-based hybrids. [PDF]

RSC Adv
Altwaijry NA, Othman IMM, Anwar MM, Nosier SS, Saleh A, Tashkandi NY, Nossier ES.   +6 more
europepmc   +1 more source

Dimeric Anthraquinone Rugulosin A Induces Apoptosis in Lung Adenocarcinoma and Targets PI3K/AKT/MAPK Pathways <i>In Silico</i>. [PDF]

ACS Omega
Manzano JAH, Abellanosa EAM, Aguilar JPP, Brogi S, Yen CH, Notarte KI, Austriaco N, Macabeo APG.   +7 more
europepmc   +1 more source

Antitumor Activity of Sodium Selenite, Palbociclib, and Disulfiram Against Osteosarcoma and Rhabdomyosarcoma Cell Lines

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Osteosarcoma and rhabdomyosarcoma are the most common pediatric sarcomas, yet prognosis remains poor due to high relapse rates. This study investigates the repurposing of palbociclib (PB) and disulfiram (DS), alongside sodium selenite (SS), as potential therapeutic strategies.
María Ángeles Chico, Kevin Doello, Raul Ortiz, Mercedes Peña, Consolación Melguizo, Cristina Mesas, Jose Prados   +6 more
wiley   +1 more source

Antiproliferative activity of Moringa oleifera (L.) Lam. and Moringa stenopetala (Bak.) Cufod. leaves extract against selected cancer cells in primary cell culture. [PDF]

Sci Rep
Assaye MA, Fallahi P, Volterrani D, Ferrari SM, Barozzi E, Patrizio A, Tesfay H, Gebre SG.   +7 more
europepmc   +1 more source