Results 241 to 250 of about 120,892 (307)

The Pyrazole Scaffold in Anticancer Drug Discovery: A Review of Synthetic Approaches, Structure-Activity Relationships, and Target-Based Mechanism of Action. [PDF]

Int J Mol Sci
K R K, Hacholli VB, Gackowski M, Pisklak DM, Kumar A, Szeleszczuk Ł.   +5 more
europepmc   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of Fluorinated <i>N</i>-Acetylmannosamine Analogs. [PDF]

J Org Chem
Krčil A, Šutvajová L, Hamala V, Císařová I, Kurfiřt M, Červenková Št'astná L, Bernášková J, Hrstka R, Karban J.   +8 more
europepmc   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source

In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells. [PDF]

Curr Issues Mol Biol
Meral O, Balkan BM, Bestil DN, Sayiner S, Ceylanli D, Uyurca S, Pehlivan S, Ozkurt G, Kismali G, Sel T.   +9 more
europepmc   +1 more source

Total Synthesis and Antimalarial Studies of Caelestines A–C

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith, Aaron M. Lock, Vicky M. Avery, Rohan A. Davis   +3 more
wiley   +1 more source

Impact of Pretreatment Degree and Enzyme Type on the Production of Radical Scavenging and Antiproliferative Peptides from Starfish. [PDF]

Mar Drugs
Vate NK, Sharifi E, Coppola A, Montuori E, Undeland I, de Pascale D, Coppola D, Abdollahi M.   +7 more
europepmc   +1 more source

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

European Journal of Inorganic Chemistry, Volume 29, Issue 16, 4 June 2026.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone, Martina Scianna, Isabella Caligiuri, Laura Orian, Pablo Nogara, Nicola Demitri, Flavio Rizzolio, Thomas Scattolin   +7 more
wiley   +1 more source

Evaluation of the phenolic profile and biological activities of Boletus speciosus extracts optimized with response surface methodology and artificial neural networks-genetic algorithm. [PDF]

Sci Rep
Korkmaz AF.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source