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Synthesis and antiproliferative activity of alkylphosphocholines
Chemistry and Physics of Lipids, 2003Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using omega-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to ...
M. AGRESTA +7 more
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Antioxidant and Antiproliferative Activities of Strawberries
Journal of Agricultural and Food Chemistry, 2003Strawberries contain high levels of antioxidants, which have been correlated with a decreased risk of chronic disease. To more fully characterize the antioxidant profiles and possible associated health benefits of this fruit, the total free and bound phenolic, total flavonoid, and total anthocyanin contents of eight strawberry cultivars (Earliglow ...
Katherine J, Meyers +3 more
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Targeting silibinin in the antiproliferative pathway
Expert Opinion on Investigational Drugs, 2010Due to the failure and severe toxicity of cancer chemotherapy, silibinin, a natural flavonoid from the seeds of milk thistle, has recently received more attention for its potential anticancer and nontoxic roles in animals and humans. Silibinin has clearly demonstrated inhibition of multiple cancer cell signaling pathways, including growth inhibition ...
Lei, Li, Jin, Zeng, Ye, Gao, Dalin, He
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Vasorelaxant and antiproliferative effects of berberine
European Journal of Pharmacology, 2000The present study was intended to examine the relaxant effects of berberine in rat isolated mesenteric arteries. Berberine produced a rightward shift of the concentration-response curve to phenylephrine and significantly reduced the maximal contractile response to phenylephrine.
W H, Ko +7 more
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Antiproliferative Effects of the Enantiomers of Flurbiprofen
The Journal of Clinical Pharmacology, 1996Nonsteroidal antiinflammatory drugs (NSAIDs) are recognized for inhibiting growth of colon tumors in animal models, and for reducing the risk of colon cancer in humans. The mechanisms involved have not been established, but are thought to be related to reduced prostaglandin biosynthesis.
J D, McCracken +7 more
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Methotrexate: Anti-inflammatory or antiproliferative?
Journal of the American Academy of Dermatology, 1990Editorial presentant le mecanisme d'action du methotrexate et son utilisation dans le traitement du psoriasis.
M D, Zanolli +2 more
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Cutaneous uses of the antiproliferative drugs
Clinical Pharmacology & Therapeutics, 1974The fortuitous observations of Richard Gubner, an internist, that psoriasis responded to systemic treatment with the antimetabolic agent aminopterin stimulated an interest in the use of anti proliferative drugs for skin diseases.10 The subsequent reports of Rees, Bennett, and Bostick,22 VanScott, Auerbach, and Weinstein,27 Callaway, McAfee, and ...
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Antiproliferative Action of Vitamin D
2002During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration increases especially the risk of hormone-related cancers.
Timo, Ylikomi +9 more
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Antiproliferative effects of NO synthase products
Research in Immunology, 1991M, Lepoivre +4 more
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Antiproliferative and Anti-Tumor Activity of Organotin Compounds
Coordination Chemistry Reviews, 2009Sotiris K Hadjikakou, Nick Hadjiliadis
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