Results 261 to 270 of about 120,892 (307)

Antiproliferative effects of peracetylated naphthoxylosides

Bioorganic & Medicinal Chemistry Letters, 2009
The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs.
Ulrika, Nilsson, Mårten, Jacobsson, Richard, Johnsson, Katrin, Mani, Ulf, Ellervik   +4 more
core   +4 more sources

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

International Journal of Molecular Sciences, 2018
Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents.
Xu Hu, Dahong Li, Chun Chu
exaly   +2 more sources

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Antiproliferatives and Transplantation

2021
Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication.
Robert, Donovan, Howard, Eisen, Omaima, Ali   +2 more
openaire   +2 more sources

A Review on Acridines as Antiproliferative Agents

Mini-Reviews in Medicinal Chemistry, 2022
Abstract: Acridine derivatives have been thoroughly investigated and discovered to have multitarget qualities, inhibiting topoisomerase enzymes that regulate topological changes in DNA and interfering with DNA's vital biological function. This article discusses current progress in the realm of novel 9-substituted acridine heterocyclic compounds ...
Kalirajan Rajagopal, Aparna Baliwada, Potlapati Varakumar, Kannan Raman, Gowramma Byran   +4 more
openaire   +2 more sources

Antiproliferative properties of piperidinylchalcones

Bioorganic & Medicinal Chemistry, 2006
Methoxylated chalcones bearing N-methylpiperidinyl substituents on ring A inhibited the growth of human tumour cell lines (MCF, HCT 116, and Jurkat) at IC50 values of
Liu, X., Go, M.-L.
openaire   +2 more sources

New antiproliferative benzoindolinothiazepines derivatives

European Journal of Medicinal Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Guillaume, Laconde, Patrick, Depreux, Pascal, Berthelot, Nicole, Pommery, Jean-Pierre, Hénichart   +4 more
openaire   +2 more sources

Cardiotoxicity of the Antiproliferative Compound Fluorouracil

Drugs, 1999
The antimetabolite fluorouracil (5-FU) is frequently administered for chemotherapy of various malignant neoplasms. The drug is well known for its adverse effects involving bone marrow, skin, mucous membranes, intestinal tract and central nervous system, whereas its cardiotoxicity is less familiar to clinicians.
K, Becker, J F, Erckenbrecht, D, Häussinger, T, Frieling   +3 more
openaire   +2 more sources

Synthesis and antiproliferative activity of retroetoposide

Bioorganic & Medicinal Chemistry Letters, 2003
Retro-4'-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4'-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-beta-D-glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.
Philippe, Meresse, Prokopios, Magiatis, Emmanuel, Bertounesque, Claude, Monneret   +3 more
openaire   +2 more sources

Antioxidant and Antiproliferative Activities of Raspberries

Journal of Agricultural and Food Chemistry, 2002
Raspberries are rich in phenolic phytochemicals. To study the health benefits of raspberries, four fresh raspberry varieties (Heritage, Kiwigold, Goldie, and Anne) were evaluated for total antioxidant and antiproliferative activities. The total amount of phenolics and flavonoids for each of the four raspberry varieties was determined.
Ming, Liu, Xin Qi, Li, Courtney, Weber, Chang Yong, Lee, Janice, Brown, Rui Hai, Liu   +5 more
openaire   +2 more sources

Approach to the isolation of antiproliferative genes

Experimental Gerontology, 1989
Poly(A) RNAs from normal rat liver and senescent human fibroblasts appear to have more antiproliferative activity than RNAs from regenerating rat liver and early passage human fibroblasts. We have screened two rat liver and one human liver library by differential hybridization and isolated four candidate cDNAs for this antiproliferative activity; one ...
M J, Nuell, J K, McClung, J R, Smith, D B, Danner   +3 more
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