Results 251 to 260 of about 136,781 (306)

Cardiotoxicity of the Antiproliferative Compound Fluorouracil

Drugs, 1999
The antimetabolite fluorouracil (5-FU) is frequently administered for chemotherapy of various malignant neoplasms. The drug is well known for its adverse effects involving bone marrow, skin, mucous membranes, intestinal tract and central nervous system, whereas its cardiotoxicity is less familiar to clinicians.
K, Becker, J F, Erckenbrecht, D, Häussinger, T, Frieling   +3 more
openaire   +2 more sources

Synthesis and antiproliferative activity of retroetoposide

Bioorganic & Medicinal Chemistry Letters, 2003
Retro-4'-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4'-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-beta-D-glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.
Philippe, Meresse, Prokopios, Magiatis, Emmanuel, Bertounesque, Claude, Monneret   +3 more
openaire   +2 more sources

Antiproliferative effects of amphiphilic molecules

International Journal of Immunopharmacology, 1990
Previous investigations indicated that certain long chain amphiphiles possess immunosuppressive activity. Here we tested this concept by studying the ability of a series of nitrogen-containing amphiphiles of varying hydrocarbon chain lengths to inhibit the human mixed lymphocyte reaction (MLR). Seventeen of 29 compounds were classified as inhibitory in
E A, Coy, A K, Reddy, J J, Hostynek, G J, Gleich   +3 more
openaire   +2 more sources

Approach to the isolation of antiproliferative genes

Experimental Gerontology, 1989
Poly(A) RNAs from normal rat liver and senescent human fibroblasts appear to have more antiproliferative activity than RNAs from regenerating rat liver and early passage human fibroblasts. We have screened two rat liver and one human liver library by differential hybridization and isolated four candidate cDNAs for this antiproliferative activity; one ...
M J, Nuell, J K, McClung, J R, Smith, D B, Danner   +3 more
openaire   +2 more sources

An antiproliferative bioassay for interleukin-4

Journal of Immunological Methods, 1996
Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page, M S, Topp, R, Thorpe, A R, Mire-Sluis   +3 more
openaire   +2 more sources

THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)

International Journal of Oncology, 1995
Cellular mortal and immortal phenotypes as defined by the limited and the infinite capacity of cells to divide are the characteristics of normal and cancerous cells in culture. Numerous strategies that have been employed to understand the mechanism(s) of normal as well as tumor cell growth have revealed that these are genetically controlled, however ...
R, Wadhwa, Y, Mitsui, T, Ide, S, Kaul
openaire   +2 more sources

Antioxidant and Antiproliferative Activities of Raspberries

Journal of Agricultural and Food Chemistry, 2002
Raspberries are rich in phenolic phytochemicals. To study the health benefits of raspberries, four fresh raspberry varieties (Heritage, Kiwigold, Goldie, and Anne) were evaluated for total antioxidant and antiproliferative activities. The total amount of phenolics and flavonoids for each of the four raspberry varieties was determined.
Ming, Liu, Xin Qi, Li, Courtney, Weber, Chang Yong, Lee, Janice, Brown, Rui Hai, Liu   +5 more
openaire   +2 more sources

Selective antiproliferative effects of thymidine

Experientia, 1993
A substance with antiproliferative bioactivity in an aqueous extract of Cordyline terminalis was purified and identified by mass spectrometry to be the natural nucleoside, thymidine. 10(-5) M Thymidine inhibited EL4 cell replication and decreased cell viability after 12-24 h. The effect was highly specific for this nucleoside.
Ooi, S.O., Sim, K.Y., Chung, M.C.M., Kon, O.L.   +3 more
openaire   +2 more sources

Antiproliferative Effect of Somatostatin and Analogs

Chemotherapy, 2001
Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects.
C, Bousquet, E, Puente, L, Buscail, N, Vaysse, C, Susini   +4 more
openaire   +2 more sources

Antiproliferative Drugs for Restenosis Prevention

Interventional Cardiology Clinics, 2016
Cardiovascular disease is a leading cause of death and disability worldwide. Current treatment strategies aimed at treating the symptoms and consequences of obstructive vascular disease have embraced both optimal medical therapy and catheter-based percutaneous coronary intervention with drug-eluting stents.
Anwer, Habib, Aloke Virmani, Finn
openaire   +2 more sources