Results 271 to 280 of about 186,437 (313)

Total Synthesis of Antiproliferative Parvifloron F

Organic Letters, 2018
The first total synthesis of parvifloron F, a bioactive highly oxidized abietane diterpene, was achieved. The abietane skeleton was constructed by Lewis acid promoted cyclization. Preliminary structure-activity relationship correlations were established for the synthetic intermediates against human tumor cell lines.
Yohei Saito, Masuo Goto, Kyoko Nakagawa-Goto   +2 more
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Antiproliferative steroidal glycosides from Digitalis ciliata

Fitoterapia, 2012
Two new compounds, a furostanol glycoside (1) and a pregnane glycoside (4), along with eight known compounds, belonging to the classes of spirostane (2,3), pregnane (5-7) and cardenolide (8-10) glycosides, were isolated from the seeds of Digitalis ciliata. Their structures were elucidated by 1D and 2D-NMR experiments as well as ESI-MS analysis. For the
PERRONE, ANGELA, CAPASSO, Anna, FESTA, MICHELA, E. Kemertelidze, PIZZA, Cosimo, A. Skhirtladze, PIACENTE, Sonia   +6 more
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Antiproliferative and Cytotoxic Activities

2018
Cancer is a genetic disease, affecting many people worldwide. Chemotherapy is routinely used for cancer treatment. However, this therapeutic approach is not always effective due to the development of cell resistance and toxic effects. Plants are a reservoir of natural chemicals with chemoprotective potential against cancer and with low adverse effects.
Anesini, Claudia Alejandra, Alonso, Maria del Rosario, Martino, Renzo Fabricio   +2 more
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An antiproliferative bioassay for interleukin-4

Journal of Immunological Methods, 1996
Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page, M S, Topp, R, Thorpe, A R, Mire-Sluis   +3 more
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Antiproliferative Triterpenes from Melaleuca ericifolia

Journal of Natural Products, 2008
Three new 28-norlupane triterpenes, 28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide (1), 28-norlup-20(29)-en-3beta-hydroxy-17alpha-hydroperoxide (2), and 20 S-17beta,29-epoxy-28-norlupan-3beta-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes.
Fatma M, Abdel Bar, Ahmed M, Zaghloul, Sunitha V, Bachawal, Paul W, Sylvester, Kadria F, Ahmad, Khalid A, El Sayed   +5 more
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Antiproliferative Device Coatings

Journal of the American College of Cardiology, 2021
Zeller, Thomas, Böhme, Tanja
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Cardiotoxicity of the Antiproliferative Compound Fluorouracil

Drugs, 1999
The antimetabolite fluorouracil (5-FU) is frequently administered for chemotherapy of various malignant neoplasms. The drug is well known for its adverse effects involving bone marrow, skin, mucous membranes, intestinal tract and central nervous system, whereas its cardiotoxicity is less familiar to clinicians.
K, Becker, J F, Erckenbrecht, D, Häussinger, T, Frieling   +3 more
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New Antiproliferative Immunosuppressive Agents

Journal of Pharmacy Practice, 2003
Since the early 1980s, the combination of cyclosporine, azathioprine, and prednisone has been the mainstay tripledrug immunosuppressive regimen used in transplantation. However, advances in drug research, design, and development have allowed for the introduction of new agents that have greatly increased the number of immunosuppressive agents available ...
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Chalcogen-Containing Phenolics as Antiproliferative Agents

Future Medicinal Chemistry, 2018
The increasing number of cancer cases has stimulated researchers to seek for novel approaches. We have combined two bioactive moieties: a polyphenolic scaffold and an organoselenium motif. Four different families (isothiocyanates/thioureas, and their selenium isosters) derived from dopamine, (±)-norepinephrine and R-epinephrine were accessed ...
Paloma, Begines, Ana, Oliete, Óscar, López, Inés, Maya, Gabriela B, Plata, José M, Padrón, José G, Fernández-Bolaños   +6 more
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Synthesis and antiproliferative activity of retroetoposide

Bioorganic & Medicinal Chemistry Letters, 2003
Retro-4'-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4'-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-beta-D-glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.
Philippe, Meresse, Prokopios, Magiatis, Emmanuel, Bertounesque, Claude, Monneret   +3 more
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