Results 271 to 280 of about 120,892 (307)
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An antiproliferative bioassay for interleukin-4
Journal of Immunological Methods, 1996Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page +3 more
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THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)
International Journal of Oncology, 1995Cellular mortal and immortal phenotypes as defined by the limited and the infinite capacity of cells to divide are the characteristics of normal and cancerous cells in culture. Numerous strategies that have been employed to understand the mechanism(s) of normal as well as tumor cell growth have revealed that these are genetically controlled, however ...
R, Wadhwa, Y, Mitsui, T, Ide, S, Kaul
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Antiproliferative effects of amphiphilic molecules
International Journal of Immunopharmacology, 1990Previous investigations indicated that certain long chain amphiphiles possess immunosuppressive activity. Here we tested this concept by studying the ability of a series of nitrogen-containing amphiphiles of varying hydrocarbon chain lengths to inhibit the human mixed lymphocyte reaction (MLR). Seventeen of 29 compounds were classified as inhibitory in
E A, Coy +3 more
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Selective antiproliferative effects of thymidine
Experientia, 1993A substance with antiproliferative bioactivity in an aqueous extract of Cordyline terminalis was purified and identified by mass spectrometry to be the natural nucleoside, thymidine. 10(-5) M Thymidine inhibited EL4 cell replication and decreased cell viability after 12-24 h. The effect was highly specific for this nucleoside.
Ooi, S.O. +3 more
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Antiproliferative Effect of Somatostatin and Analogs
Chemotherapy, 2001Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects.
C, Bousquet +4 more
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Antiproliferative Drugs for Restenosis Prevention
Interventional Cardiology Clinics, 2016Cardiovascular disease is a leading cause of death and disability worldwide. Current treatment strategies aimed at treating the symptoms and consequences of obstructive vascular disease have embraced both optimal medical therapy and catheter-based percutaneous coronary intervention with drug-eluting stents.
Anwer, Habib, Aloke Virmani, Finn
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Synthesis and antiproliferative activity of alkylphosphocholines
Chemistry and Physics of Lipids, 2003Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using omega-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to ...
M. AGRESTA +7 more
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Cutaneous uses of the antiproliferative drugs
Clinical Pharmacology & Therapeutics, 1974The fortuitous observations of Richard Gubner, an internist, that psoriasis responded to systemic treatment with the antimetabolic agent aminopterin stimulated an interest in the use of anti proliferative drugs for skin diseases.10 The subsequent reports of Rees, Bennett, and Bostick,22 VanScott, Auerbach, and Weinstein,27 Callaway, McAfee, and ...
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Antioxidant and Antiproliferative Activities of Strawberries
Journal of Agricultural and Food Chemistry, 2003Strawberries contain high levels of antioxidants, which have been correlated with a decreased risk of chronic disease. To more fully characterize the antioxidant profiles and possible associated health benefits of this fruit, the total free and bound phenolic, total flavonoid, and total anthocyanin contents of eight strawberry cultivars (Earliglow ...
Katherine J, Meyers +3 more
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Targeting silibinin in the antiproliferative pathway
Expert Opinion on Investigational Drugs, 2010Due to the failure and severe toxicity of cancer chemotherapy, silibinin, a natural flavonoid from the seeds of milk thistle, has recently received more attention for its potential anticancer and nontoxic roles in animals and humans. Silibinin has clearly demonstrated inhibition of multiple cancer cell signaling pathways, including growth inhibition ...
Lei, Li, Jin, Zeng, Ye, Gao, Dalin, He
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