Results 211 to 220 of about 186,437 (313)

Ultrasound-Assisted Synthesis and Biological Profiling of 1,3,5-Triazine Derivatives with Antiproliferative Activity in Triple-Negative Breast Cancer. [PDF]

Curr Issues Mol Biol
Bosak N, Drabczyk AK, Jaśkowska J, Stachowicz-Suhs M, Filip-Psurska B, Boguszewska-Czubara A, Greber KE, Ciura K, Kułaga D.   +8 more
europepmc   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

Triazole and Pyrazole Hybrids of Electrophilic Natural Products as Promising Anticancer Agents. [PDF]

Molecules
Fermo AD, Bisi A, Orioli R, Gobbi S, Belluti F.   +4 more
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Quinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications. [PDF]

Biomol Ther (Seoul)
Alhuwayshil J, Alnajim N, Dulaym SB, Alamre J, Alsubait A, Mohammed AE, Alghamdi SS.   +6 more
europepmc   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Editorial expression of concern: Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. [PDF]

Reprod Biol Endocrinol
Guo J, Schally AV, Zarandi M, Varga J, Leung PC.   +4 more
europepmc   +1 more source

Triple‐Negative Breast Cancer Versus Non‐Triple‐Negative Breast Cancer: The Impact of Pd and Pt Complexes on Basal‐Like Triple‐Negative Breast Cancer

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
The anticancer activity of the complexes Pd3Spd2, Pt3Spd2, Pt2Put2(NH3)4 and Pd2Put2 against human TNBC, non‐TNBC and healthy breast cells was evaluated. The metabolic impact of the most promising metal complexes—Pd3Spd2 and Pt2Put2(NH3)4—was further assessed using vibrational microspectroscopies, providing detailed insights into the drug‐induced ...
Clara B. Martins, Maria P. M. Marques, Luís A. E. Batista de Carvalho, Ana L. M. Batista de Carvalho   +3 more
wiley   +1 more source

Synthesis and Development of 3-((2,4-Difluorophenyl)Amino)Propanoic Acid Derivatives as an Antiproliferative Medicinal Chemistry Scaffold Targeting Growth Factor Receptors. [PDF]

Pharmaceuticals (Basel)
Pranaitytė G, Kavaliauskas P, Petraitis V, Petraitienė R, Grigalevičiūtė R, Ivanauskas L, Marksa M, Duda G, Acevedo W, Grybaitė B, Mickevičius V.   +10 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source