Results 211 to 220 of about 90,202 (264)

Antiproliferative effects of amphiphilic molecules

International Journal of Immunopharmacology, 1990
Previous investigations indicated that certain long chain amphiphiles possess immunosuppressive activity. Here we tested this concept by studying the ability of a series of nitrogen-containing amphiphiles of varying hydrocarbon chain lengths to inhibit the human mixed lymphocyte reaction (MLR). Seventeen of 29 compounds were classified as inhibitory in
E A, Coy, A K, Reddy, J J, Hostynek, G J, Gleich   +3 more
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Approach to the isolation of antiproliferative genes

Experimental Gerontology, 1989
Poly(A) RNAs from normal rat liver and senescent human fibroblasts appear to have more antiproliferative activity than RNAs from regenerating rat liver and early passage human fibroblasts. We have screened two rat liver and one human liver library by differential hybridization and isolated four candidate cDNAs for this antiproliferative activity; one ...
M J, Nuell, J K, McClung, J R, Smith, D B, Danner   +3 more
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An antiproliferative bioassay for interleukin-4

Journal of Immunological Methods, 1996
Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page, M S, Topp, R, Thorpe, A R, Mire-Sluis   +3 more
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Antioxidant and Antiproliferative Activities of Raspberries

Journal of Agricultural and Food Chemistry, 2002
Raspberries are rich in phenolic phytochemicals. To study the health benefits of raspberries, four fresh raspberry varieties (Heritage, Kiwigold, Goldie, and Anne) were evaluated for total antioxidant and antiproliferative activities. The total amount of phenolics and flavonoids for each of the four raspberry varieties was determined.
Ming, Liu, Xin Qi, Li, Courtney, Weber, Chang Yong, Lee, Janice, Brown, Rui Hai, Liu   +5 more
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Selective antiproliferative effects of thymidine

Experientia, 1993
A substance with antiproliferative bioactivity in an aqueous extract of Cordyline terminalis was purified and identified by mass spectrometry to be the natural nucleoside, thymidine. 10(-5) M Thymidine inhibited EL4 cell replication and decreased cell viability after 12-24 h. The effect was highly specific for this nucleoside.
Ooi, S.O., Sim, K.Y., Chung, M.C.M., Kon, O.L.   +3 more
openaire   +2 more sources

Antiproliferative Effect of Somatostatin and Analogs

Chemotherapy, 2001
Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects.
C, Bousquet, E, Puente, L, Buscail, N, Vaysse, C, Susini   +4 more
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Antiproliferative Drugs for Restenosis Prevention

Interventional Cardiology Clinics, 2016
Cardiovascular disease is a leading cause of death and disability worldwide. Current treatment strategies aimed at treating the symptoms and consequences of obstructive vascular disease have embraced both optimal medical therapy and catheter-based percutaneous coronary intervention with drug-eluting stents.
Anwer, Habib, Aloke Virmani, Finn
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Synthesis and antiproliferative activity of alkylphosphocholines

Chemistry and Physics of Lipids, 2003
Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using omega-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to ...
M. AGRESTA, D'ARRIGO, PAOLA, FASOLI, EZIO, D. LOSI, G. PEDROCCHI FANTONI, S. RIVA, SERVI, STEFANO, TESSARO, DAVIDE   +7 more
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Antioxidant and Antiproliferative Activities of Strawberries

Journal of Agricultural and Food Chemistry, 2003
Strawberries contain high levels of antioxidants, which have been correlated with a decreased risk of chronic disease. To more fully characterize the antioxidant profiles and possible associated health benefits of this fruit, the total free and bound phenolic, total flavonoid, and total anthocyanin contents of eight strawberry cultivars (Earliglow ...
Katherine J, Meyers, Christopher B, Watkins, Marvin P, Pritts, Rui Hai, Liu   +3 more
openaire   +2 more sources

Targeting silibinin in the antiproliferative pathway

Expert Opinion on Investigational Drugs, 2010
Due to the failure and severe toxicity of cancer chemotherapy, silibinin, a natural flavonoid from the seeds of milk thistle, has recently received more attention for its potential anticancer and nontoxic roles in animals and humans. Silibinin has clearly demonstrated inhibition of multiple cancer cell signaling pathways, including growth inhibition ...
Lei, Li, Jin, Zeng, Ye, Gao, Dalin, He
openaire   +2 more sources