Results 191 to 200 of about 90,202 (264)

Evaluation of the phenolic profile and biological activities of Boletus speciosus extracts optimized with response surface methodology and artificial neural networks-genetic algorithm. [PDF]

Sci Rep
Korkmaz AF.
europepmc   +1 more source

Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei, Atefeh Taghavi, Amir R. Afshari, Farzaneh Davoudi, Elaheh Gheybi, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

The Pyrazole Scaffold in Anticancer Drug Discovery: A Review of Synthetic Approaches, Structure-Activity Relationships, and Target-Based Mechanism of Action. [PDF]

Int J Mol Sci
K R K, Hacholli VB, Gackowski M, Pisklak DM, Kumar A, Szeleszczuk Ł.   +5 more
europepmc   +1 more source

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of Fluorinated <i>N</i>-Acetylmannosamine Analogs. [PDF]

J Org Chem
Krčil A, Šutvajová L, Hamala V, Císařová I, Kurfiřt M, Červenková Št'astná L, Bernášková J, Hrstka R, Karban J.   +8 more
europepmc   +1 more source

In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells. [PDF]

Curr Issues Mol Biol
Meral O, Balkan BM, Bestil DN, Sayiner S, Ceylanli D, Uyurca S, Pehlivan S, Ozkurt G, Kismali G, Sel T.   +9 more
europepmc   +1 more source

Intestinal Organoid-Based Mathematical Modeling Predicts Clinical Gastrointestinal Toxicity of Oral Oncology Drugs. [PDF]

CPT Pharmacometrics Syst Pharmacol
Pin C, Maheshvare M D, Gall L, Hall A, Coen M, Bianco A, Liu S, Pryde K.   +7 more
europepmc   +1 more source

Impact of Pretreatment Degree and Enzyme Type on the Production of Radical Scavenging and Antiproliferative Peptides from Starfish. [PDF]

Mar Drugs
Vate NK, Sharifi E, Coppola A, Montuori E, Undeland I, de Pascale D, Coppola D, Abdollahi M.   +7 more
europepmc   +1 more source

Evaluation of phenolic profile and multi-biological activities of Lepista glaucocana extracts optimized by ANN-GA and RSM models. [PDF]

Sci Rep
Giray G.
europepmc   +1 more source