Results 171 to 180 of about 90,202 (264)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Investigation on the Cytotoxicity of Hydroxycinnamic and Hydroxybenzoic Acid-Based Natural Antioxidant Conjugated Terpyridine Analogues toward Triple-Negative Breast Cancer. [PDF]

ACS Med Chem Lett
Roy A, Beniwal N, Shome A, Rengan AK, Chinta JP.   +4 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, Volume 20, Issue 8, Page 1986-2007, August 2026.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Integrated synthesis, antiproliferative potential, and <i>in silico</i> analysis of novel pyrazole-based hydrazones derived from 3-(2-(4-chlorophenyl)hydrazineylidene)-5-phenylfuran-2(3<i>H</i>)-one. [PDF]

RSC Adv
Ramadan SK, Kazem MSH, Kamal M, Hashem AI, Abd-Rabboh HSM, Abou-Elmagd WSI.   +5 more
europepmc   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, Volume 13, Issue 43, 3 August 2026.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Design, synthesis and antiproliferative, apoptotic, and immunomodulatory properties of new heteroaryl pyridine-linked 1,2,4-oxadiazoles as prospective dual EGFR/BRAF^V600E inhibitors. [PDF]

RSC Adv
Gomaa HAM, Shaker ME, Alzarea SI, Alatwi E, Mohamed FAM, Abdullah Alzahrani AY, Alyami BA, Bräse S, Rabea SM, Youssif BGM.   +9 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 44, 7 August 2026.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Modulation of Kombucha Functionality by Whey Protein-Encapsulated <i>Lactobacillus</i>: Effects on Bioactive Properties. [PDF]

Foods
Budimac T, Ranitović A, Šovljanski O, Vulić J, Vitas J, Gligorijević N, Vučetić A, Tomić A, Malbaša R, Cvetković D.   +9 more
europepmc   +1 more source

Donor Screening and Stoichiometry Engineering‐Driven Supramolecular Charge‐Transfer Complexes for Synergistic Tumor Near‐Infrared‐II Phototherapy

Aggregate, Volume 7, Issue 8, August 2026.
This work presents 2A‐D2, a supramolecular charge‐transfer complex via donor screening and stoichiometry modulation for near‐infrared‐II phototherapy. Optimizing the assembly ratio induces loose molecular packing, mitigating reactive oxygen species quenching while maintaining high photothermal effects. This synergistic photothermal therapy/photodynamic
Laiping Fang, Yike Tu, Shufang Li, Haiming Feng, Yu Cao, Wenqing Xiao, Jin Fang, Ping'an Ma, Wujun Geng, Guihua Jiang   +9 more
wiley   +1 more source

SOS1: tracking the evolving path from promising to actionable therapeutic target in RAS-dependent cancers. [PDF]

Mol Cancer
Luna-Ramírez L, García-Navas R, Santos E, Baltanás FC.   +3 more
europepmc   +1 more source