Results 71 to 80 of about 186,437 (313)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF^V600E Dual Inhibitors Endowed with Antiproliferative Activity

Pharmaceuticals, 2023
2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et3N at room temperature or in ethanol under reflux.
Lamya H. Al-Wahaibi, Essmat M. El-Sheref, Alaa A. Hassan, S. Bräse, M. Nieger, Bahaa G. M. Youssif, Mahmoud A. A. Ibrahim, Hendawy N. Tawfeek   +7 more
doaj   +1 more source

A theoretical study of the response of vascular tumours to different types of chemotherapy [PDF]

, 2008
In this paper we formulate and explore a mathematical model to study continuous infusion of a vascular tumour with isolated and combined blood-borne chemotherapies.
Jasmina Panovska, Helen M. Byrne, Philip K. Maini, Casciari, Sutherland, Muthukkaruppan, Baptist-Trimbos, Cheng, Stoll, Rowinsky, Sherratt, Ward, Gatenby, Sherratt, Anderson, Byrne, Orme, Orme, Breward, Breward, Hahnfield, d’Onfrio, Panovska, Griffiths, De Angelis, Baxter, Sholley, O’Reilly, O’Reilly, West, Ward, Jackson, Arakelyn, Agur, Sinek, Zheng, Fister, Fister, Balding, Edelstein, Stokes, Press, Degregorio, Jackson, Dordel, Jackson, Laderoute, Pettet   +47 more
core   +2 more sources

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Cytotoxic and Antioxidant Potential of Launaea mucronata Forssk Essential Oil Growing in Northern Saudi Arabia

Molecules, 2023
Essential oils are naturally occurring multicomponent combinations of isoprenoids with distinctive odors that are produced by aromatic plants from mevalonic acid. They are extensively applied in aromatherapy for the treatment of various ailments.
Ehab M. Mostafa, Ahmed H. El-Ghorab, Mohammed M. Ghoneim, Hasnaa Ali Ebrahim, Moaz Abulfaraj, Mohamed A. Abdelgawad, Amr Farouk, Arafa Musa   +7 more
doaj   +1 more source

MALDI-MS argininyl bufadienolide esters fingerprint from parotoid gland secretions of Rhinella arenarum : age, gender and seasonal variation [PDF]

, 2018
In many amphibians, the granular glands can be grouped in special regions forming macroglands. This is the case of toads, characterized by the presence of a pair of parotoid macroglands, strategically located to give protection by poison release in case ...
Erra Balsells, Rosa, Jungblut, Lucas David, Petroselli, Gabriela, Pozzi, Andrea Gabriela, Raices, Marilina   +4 more
core   +1 more source

Fused Xanthone Derivatives as Antiproliferative Agents

Anti-Cancer Agents in Medicinal Chemistry, 2009
Xanthones have been isolated from several natural sources, mainly belonging in Guttiferae and Gentianaceae families as secondary plant metabolites and many of them are endowed with diverse pharmacological properties. We have focused in the study of cytotoxic fused xanthone derivatives, having in mind that some furano- and pyranoxanthone natural ...
Pouli, N., Marakos, P.
openaire   +3 more sources

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie, EarlyView.
This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec, Josef Holub, Maksim A. Samsonov, Zdeňka Růžičková, Josef Cvačka, Ján Vančo, Zdeněk Trávníček, Jan Belza, Zdeněk Dvořák, Jan Vrána, Aleš Růžička   +10 more
wiley   +2 more sources

Novel perylene diimide based antiproliferative chromophores

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2023
The primary objective of the work was to monitor the antiproliferative activity of two newly synthesized and described perylene diimides. The MTT test was used to investigate the antiproliferative effect against PC3 the prostat cancer cell line, Panc1 pancreatic cancer cell line, Saos2 osteosarcoma cell line, Hep3B hepatoma cell line and HUVEC non ...
Furkan OZCİL, Hatice YILDIRIM, Merve KARAMAN, Funda YÜKRÜK   +3 more
openaire   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source