Results 71 to 80 of about 136,781 (306)

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

open access: yesAdvanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan   +12 more
wiley   +1 more source

Antiproliferative activity of terpene-phospholipids against human cancer cell lines.

open access: yes, 2017
Antiproliferative activity of terpene-phospholipids against human cancer cell lines.
Anna Gliszczyńska (2839163)   +4 more
core   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

open access: yesAdvanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen   +7 more
wiley   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

open access: yesAdvanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò   +7 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

open access: yesAdvanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab   +8 more
wiley   +1 more source

Corrigendum: Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model

open access: yesFrontiers in Pharmacology, 2023
Daniel Morales-Cano   +35 more
doaj   +1 more source

Effect of the A. phalerata oil in antiproliferative activity.

open access: yes, 2018
Effect of the A. phalerata oil in antiproliferative activity.
Fernando Freitas de Lima (3232629)   +12 more
core   +1 more source

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

open access: yesMarine Drugs, 2012
Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria.
Josafat-Marina Ezquerra-Brauer   +2 more
doaj   +1 more source

Antiproliferative activity of spinasterol isolated of Stegnosperma halimifolium (Benth, 1844)

open access: yes, 2017
Cancer is the major cause of death in the world, representing a significant public health problem. Plants have been shown as a great source of secondary metabolites with anticancer activity.
Salvador Enrique Meneses-Sagrero   +5 more
core   +1 more source

Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines

open access: yesMarine Drugs, 2019
Fucoidans extracted from brown algae exert manifold biological activities paving the way for the development of numerous applications including treatments outside tumor therapy such as age-related macular degeneration or tissue engineering. In this study,
Kaya Saskia Bittkau   +6 more
doaj   +1 more source

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