Results 81 to 90 of about 132,199 (306)

Lenalidomide, an antiproliferative CLL drug

Blood, 2014
In this issue of Blood , Fecteau et al show that lenalidomide inhibits proliferation of chronic lymphocytic leukemia (CLL) cells in vitro by targeting cereblon. Thus far, the clinical activity of this drug in CLL was believed to be mainly via the microenvironment.[1][1] ![Figure][2 ...
openaire   +3 more sources

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

, 2017
Hatem A Abdel-Aziz,1 Wagdy M Eldehna,2 Adam B Keeton,3 Gary A Piazza,3 Adnan A Kadi,4 Mohamed W Attwa,4 Ali S Abdelhameed,4 Mohamed I Attia4,5 1Department of Applied Organic Chemistry, National Research Centre, Giza, 2Department of Pharmaceutical ...
Keeton AB, Abdel-Aziz HA, Eldehna WM, Attwa MW, Attia MI, Abdelhameed AS, Piazza GA, Kadi AA   +7 more
core  

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis

Molecules, 2017
A new series of pyrazoline derivatives 1b–12b was designed, synthesized and evaluated for antiproliferative activity against three cancer cell lines (HepG-2, Hela and A549).
Hong Wang, Jinhong Zheng, Weijie Xu, Cheng Chen, Duncan Wei, Wenxiu Ni, Ying Pan   +6 more
doaj   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Antiproliferative activity of spinasterol isolated of Stegnosperma halimifolium (Benth, 1844)

, 2017
Cancer is the major cause of death in the world, representing a significant public health problem. Plants have been shown as a great source of secondary metabolites with anticancer activity.
Salvador Enrique Meneses-Sagrero, Manuel Jiménez-Estrada, Ramón Enrique Robles-Zepeda, Carmen Lizette Del-Toro-Sánchez, Eduardo Ruiz-Bustos, Moisés Navarro-Navarro   +5 more
core   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Bioactivities of endophytic Penicillia from Cupressaceae

Journal of Crop Protection, 2013
The cypress family, Cupressaceae, has a global dispersion. Currently, endophytic microorganisms from plants are being investigated for their diversity and bioactivities.
Mahdieh Hosseini Moghaddam, Jalal Soltani, Freydoun Babolhavaeji, Javad Hamzei, Sonbol Nazeri, Soheila Mirzaei   +5 more
doaj  

Synthetic Derivatives of Vinpocetine as Antiproliferative Agents

Background/Objectives: Vincamine is an indole alkaloid initially isolated from plants of the Vinca genus and has previously been demonstrated to have antioxidant, hypoglycemic, and hypolipidemic activities.
Selina Xi, Yining Xie, Arshia Desarkar, Udbhav Avadhani, Mihira Gutti, Edward Njoo, Shloka Raghavan, Melanie Tsui, Mirabelle Feng, Jennifer Luo, Stella Yang, Erika Yu, Elena Brierley-Green   +12 more
core   +1 more source

Selective Antiproliferative Activity of Hydroxynaphthyl-β-d-xylosides

, 2016
The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells.
Mattias Belting (120856), Katrin Mani (2152480), Ulf Ellervik (2160037), Mårten Jacobsson (2646469)   +3 more
core   +1 more source