Results 141 to 150 of about 1,343 (198)

Antifertility and Antiproteolytic Activity of Activated N‐Carbobenzoxy Amino Acid Esters

Journal of Pharmaceutical Sciences, 1979
N-Carbobenzoxy L-phenylalanine, glycine, L-leucine, and L-proline derivatives, their vinyl esters, and their 1,2-dibromoethyl esters were tested for antifertility activity in mice. Intraperitoneal administration reduced the pregnancy percentage and the number of fetuses per litter.
I H, Hall, J H, Drew, Z, Sajadi, L J, Loeffler   +3 more
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Study of the Antiproteolytic Activity of Fenamates and Indomethacin

Pharmacology, 1973
The effect of mefenamic acid, flufenamic acid and of indomethacin on tryptic hydrolysis of bovine albumin (BA) and of the syn thetic substrates N-benzoyl-DL.-arginine-p-nitro anilide (BAPNA) and L-lysin-p-nitroanilide (LPA) was studied in vitro. Both fenamates and indomethacin inhibited tryptic hydrolysis of BA, indomethacin being more active.
M, Stanciková, K, Trnavský
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Proteolytic and antiproteolytic activities in goat antral follicles

Animal Reproduction Science, 1990
Abstract Goat antral follicles were dissected and classified initially by size into three groups: 6 mm. Follicles less than 3 mm diameter were studied without any further classification. All others were classified according to their gross stereoscopic microscope appearance into four sub-groups.
A.M. Rosales, O. Hernandez-Perez, R. Dominguez, E. Mercado, A. Rosado   +4 more
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Anti-inflammatory, analgesic and antiproteolytic activities of some novel thiadiazoles

Pharmacological Research Communications, 1983
Eighteen novel acetyl salicyloyl/butyroyl mercapto 1,3,4-thiadiazoles have been synthesized and characterized by their elemental analyses, IR and PMR spectral studies. Their efficacy against carrageenin induced paw oedema was tested in albino rats of either sex at a dose of 100 mg/kg p.o.
M, Tandon, P, Kumar, T N, Bhalla, P, Tandon, T K, Gupta, J P, Barthwal   +5 more
openaire   +2 more sources

Aromatic tetra-amidines with antiproteolytic activity inhibit platelet aggregation and secretion

Thrombosis Research, 1989
We have investigated the possibility that TAPP-H may control platelet aggregation and serotonin release induced by a series of physiological and non-physiological stimuli, that are selected on the ground of their molecular mechanism. The search of new antiplatelet molecules may have relevant implications in the therapy of haemostasis ...
L, Milani, R, Ferroni, M, Zaccarini, S, Traniello   +3 more
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Anti‐Inflammatory, Antiproteolytic and Analgesic Activities of Some New Thiadiazolyl Indoles

Archiv der Pharmazie, 1983
Abstract3‐[(2‐Aminomethyl)‐5‐mercapto‐1,3,4‐thiadiazolyl]indole (1), obtained by Mannich condensation of 2‐amino‐5‐mercapto‐1,3,4‐thiadiazole with indole and formaldehyde, was subjected to mercaptoetherification with epichlorohydrin to yield 3‐[(2‐aminomethyl)‐5‐(3‐epoxypropylmercapto)‐1,3,4‐thiadiazolyl] indole (2), which, on hydrolysis with NaOH and ...
M, Tandon, J P, Barthwal, T N, Bhalla, P, Tandon, K P, Bhargava   +4 more
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Aromatic tetra-amidines: synthesis of halo-derivatives and their antiproteolytic activity.

Il Farmaco; edizione scientifica, 1984
Mono-halo derivatives of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)p ropane (TAPP-H) have been synthesized and their inhibitory effect on the bovine trypsin, bovine thrombin and porcine pancreatic kallikrein catalyzed hydrolysis of p-nitroanilides of amino acids was investigated, at pH 8.1 and 37 degrees, in parallel with that of TAPP-H
FERRONI R, MENEGATTI E, GUARNERI M, TADDEO U, BOLOGNESI M, ASCENZI, Paolo, AMICONI G.   +6 more
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Antiinflammatory and antiproteolytic activities of newer indolyl isoquinolines.

Arzneimittel-Forschung, 1983
Several indolyl isoquinoline derivatives were synthesized and evaluated for their antiinflammatory and antiproteolytic activities. These derivatives possessed 9.2-32.4% inhibition at a dose of 100 mg/kg i.p. against carrageenin-induced oedema. Four of these derivatives (IVb, IVd, IVe and IVk) exhibited high potency in inhibiting oedema.
M, Tandon, P, Tandon, J P, Barthwal, T N, Bhalla, K P, Bhargava   +4 more
openaire   +1 more source

Proteolytic and Antiproteolytic Activity in the Skin: Gluing the Pieces Together

Journal of Investigative Dermatology
Epidermal differentiation is ultimately aimed at the formation of a functional barrier capable of protecting the organism from the environment while preventing loss of biologically vital elements. Epidermal differentiation entails a delicately regulated process of cell-cell junction formation and dissolution to enable upward cell migration and ...
Alon Peled, Eli Sprecher
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ChemInform Abstract: SYNTHESIS OF ANTIPROTEOLYTICALLY ACTIVE Nα‐ARYLSULFONYLATED AMIDINOPHENYLALANINE AMIDES

Chemischer Informationsdienst, 1982
AbstractDie saure Hydrolyse der 3‐ bzw. 4‐Cyanbenzylacetaminomalonester (I) ergibt die Phenylalanine (II), die mit Arylsulfonylchloriden (III) die Sulfonamide (IV) bilden und mit Thionylchlorid zu den Säurechloriden (V) reagieren.
G. WAGNER, H. HORN, P. RICHTER, H. VIEWEG, I. LISCHKE, H. G. KAZMIROWSKI   +5 more
openaire   +1 more source