Results 21 to 30 of about 1,343 (198)
PTHG2 Reduces Bone Loss in Ovariectomized Mice by Directing Bone Marrow Mesenchymal Stem Cell Fate
Stem Cells International, Volume 2021, Issue 1, 2021., 2021 Teriparatide, also known as 1‐34 parathyroid hormone (PTH (1‐34)), is commonly used for the treatment of osteoporosis in postmenopausal women. But its therapeutic application is restricted by poor metabolic stability, low bioavailability, and rapid clearance.
Jiao Chen +10 more
wiley +1 more source
The inhibitory role of sympathetic nervous system in the Ca2+-dependent proteolysis of skeletal muscle [PDF]
, 2009 Mammalian cells contain several proteolytic systems to carry out the degradative processes and complex regulatory mechanisms to prevent excessive protein breakdown.
BAVIERA, A.M. +2 more
core +2 more sources
Multifunctional Cinnamic Acid Derivatives
Molecules, 2017 Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol.
Aikaterini Peperidou +4 more
doaj +1 more source
Anais da Academia Brasileira de Ciências, 2023 Although there are reports that polyphenol resveratrol (Rsv) may cause muscle hypertrophy in basal conditions and attenuate muscle wasting in catabolic situations, its mechanism of action is still unclear.
IVANILDO I.S. JÚNIOR +11 more
doaj +1 more source
Deciphering the phylogenetic history of neuroserpin orthologs across metazoans by analysis of synteny and rare genomic characters [PDF]
, 2008 The superfamily of serine proteinase inhibitors (serpins) is involved in wide arrays of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression. The average protein
Abhishek Kumar, Hermann Ragg
core +2 more sources
Different selectivities of oxidants during oxidation of methionine residues in the α-1-proteinase inhibitor [PDF]
, 1989 Oxidation of the reactive site methionine (Met) in α-1-proteinase inhibitor (α-1-PI) to methionine sulfoxide (Met(O)) is known to cause depletion of its elastase inhibitory activity.
Daha, Mohamed R +7 more
core +2 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Mesenchymal stem/stromal cell (MSC)–based therapies for low back pain and intervertebral disc (IVD) degeneration have been emerging, despite the poor knowledge of their full mechanism of action. As failure of the annulus fibrosus (AF) is often associated
Raquel M. Gonçalves +12 more
doaj +1 more source
The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and-9 and invasion by leukemic THP-1 cells [PDF]
, 2003 The ubiquitous proteases μ- and m-calpain are Ca2+-dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoietic cells and ...
Croall D. E. +8 more
core +1 more source
Multitarget Molecular Hybrids of Cinnamic Acids
Molecules, 2014 In an attempt to synthesize potential new multitarget agents, 11 novel hybrids incorporating cinnamic acids and paracetamol, 4-/7-hydroxycoumarin, benzocaine, p-aminophenol and m-aminophenol were synthesized.
Aikaterini Peperidou +3 more
doaj +1 more source
Сучасні медичні технології, 2021 Purpose of the study. Establishing the role of processes of proteolysis of mixed saliva in the development and course of lichen planus of the oral mucosa. Materials and methods. A comprehensive examination of 102 patients with lichen planus aged 21 to
N. G. Barannik +4 more
doaj +1 more source