Results 111 to 120 of about 16,319 (219)

Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena [PDF]

, 2012
A series 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines (43 compounds), some of which are epidermal growth 22 factor tyrosine kinase inhibitors, were tested for their protozoal toxicity using an environmental Tetrahy- 23 mena strain as model organism.
Charnock, Colin, Hoff, Bård Helge, Kaspersen, Svein Jacob, Sundby, Eirik   +3 more
core   +4 more sources

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

Molecules, 2015
Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human African trypanosomiasis (sleeping sickness), Chagas ...
Therese Ellendorff, Reto Brun, Marcel Kaiser, Jandirk Sendker, Thomas J. Schmidt   +4 more
doaj   +1 more source

Synthesis and antiprotozoal activity of some imidazoles derivatives

Journal of Pharmacy and Pharmacology, 1964
Abstract The synthesis and in vitro antiprotozoal activity of a series of nitroimidazoles are described. A substituted phenyl group and, in many of the compounds, a N-substituent were also present: vinylogues of some of the compounds are described.
G P, ELLIS, C, EPSTEIN, C, FITZMAURICE, L, GOLBERG, G H, LORD   +4 more
openaire   +2 more sources

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]

, 2015
We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert, Clos, Victòria, Gbedema, Stephen Y., Kelly, John M., Muñoz-Torrero López-Ibarra, Diego, Pérez Fernández, Belén, Sola, Irene, Taylor, Martin C., Wright, Colin W.   +8 more
core   +2 more sources

Bibenzyl Derivatives from Radula voluta (An Ecuadorian Liverwort): Bioprospecting for Antiprotozoal Properties

Molecules
Phytochemical investigation of Radula voluta, a liverwort species collected in the Ecuadorian Amazon, led to the isolation of four known bibenzyl derivatives: 2-prenyl-3,5-dihydroxy-bibenzyl (1), 2-geranyl-3,5-dihydroxybibenzyl (2), 2,2-dimethyl-5 ...
José Miguel Andrade, Carlos J. Bethencourt-Estrella, Javier Chao-Pellicer, Luis Cartuche, Vladimir Morocho, Ángel Benítez, Rubén L. Rodríguez-Expósito, José E. Piñero, Jacob Lorenzo-Morales, Ana R. Díaz-Marrero, José J. Fernandez   +10 more
doaj   +1 more source

Antiprotozoal Activity of Extracts of five Turkish Lamiaceae Species

Natural Product Communications, 2011
The in vitro antiprotozoal activities of crude methanolic extracts from the aerial parts of five Lamiaceae plants ( Salvia tomentosa, S. sclarea, S. dichroantha, Nepeta nuda subsp. nuda and Marrubium astracanicum subsp.
Hasan Kirmizibekmez, Irem Atay, Marcel Kaiser, Erdem Yesilada, Deniz Tasdemir   +4 more
doaj   +1 more source

The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds

Marine Drugs, 2010
Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis.
Zulema Cantillo-Ciau, Rosa Moo-Puc, Leovigildo Quijano, Yolanda Freile-Pelegrín   +3 more
doaj   +1 more source

Novel quinoline derivatives with broad‐spectrum antiprotozoal activities

Archiv der Pharmazie
AbstractSeveral quinoline derivatives incorporating arylnitro and aminochalcone moieties were synthesized and evaluated in vitro against a broad panel of trypanosomatid protozoan parasites responsible for sleeping sickness (Trypanosoma brucei rhodesiense), nagana (Trypanosoma brucei brucei), Chagas disease (Trypanosoma cruzi), and leishmaniasis ...
Carla B. Hartman, Phelelisiwe S. Dube, Lesetja J. Legoabe, Natascha Van Pelt, An Matheeussen, Guy Caljon, Richard M. Beteck   +6 more
openaire   +3 more sources

Investigation of the Antiparasitic Potential of Luteolin: in vitro Activity and Comparison with Standard Therapeutics

Türkiye Parazitoloji Dergisi
Objective: Due to the limitations of current therapeutic approaches in treating parasitic diseases, there is a growing need for new and effective products, prompting interest in alternative approaches such as medicinal plants.
Evren Tileklioğlu, Elif Aydın
doaj   +1 more source

Synthetic Analogs of the Alkaloid Cassiarin A with Enhanced Antimalarial Activity

Pharmaceuticals
Background: Among the alkaloids from Cassia siamea, cassiarin A has outstanding antiprotozoal activity, but structure–activity relationships for this chemotype were only poorly understood until now. Methods: We worked out efficient approaches to hitherto
Thomas Klaßmüller, Timo Reiß, Florian Lengauer, Che Julius Ngwa, Karin Bartel, Gabriele Pradel, Franz Bracher   +6 more
doaj   +1 more source