Results 131 to 140 of about 8,234 (175)

Antiprotozoal activity of Senna racemosa

Journal of Ethnopharmacology, 2007
Methanol extracts of leaves, roots and bark of Senna racemosa (Mill.) H.S. Irwin & Barneby (syn. Cassia racemosa Mill.) were tested for antiprotozooal activity against Giardia intestinalis and Entamoeba histolytica. All of the tested extracts showed good activity against both protozoa species.
Rosa E, Moo-Puc, Gonzalo J, Mena-Rejon, Leovigildo, Quijano, Roberto, Cedillo-Rivera   +3 more
openaire   +2 more sources

Antiprotozoal activity of Neurolaena lobata

Phytotherapy Research, 2001
AbstractExtracts, fractions and sesquiterpene lactones from Neurolaena lobata (L.) R. Br. (Asteraceae), a traditional medicinal plant from Guatemala, were tested in vitro against Leishmania spp. promastigotes, Trypanosoma cruzi trypomastigotes and epimastigotes and Trichomonas vaginalis trophozoites. The ethanol extract inhibited the parasite growth of
Berger, Ingeborg, Paßreiter, Claus Martin, Caceres, Armando, Kubelka, Wolfgang   +3 more
openaire   +2 more sources

Antiprotozoal activity of Betulinic acid derivatives

Phytomedicine, 2010
Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity.
D B, Domínguez-Carmona, F, Escalante-Erosa, K, García-Sosa, G, Ruiz-Pinell, D, Gutierrez-Yapu, M J, Chan-Bacab, A, Giménez-Turba, L M, Peña-Rodríguez   +7 more
openaire   +2 more sources

Antiprotozoal and Anthelmintic Activity of Zinc Oxide Nanoparticles

Current Medicinal Chemistry, 2022
: Nanomaterials represent a wide alternative for the treatment of several diseases that affect both human and animal health. The use of these materials consists, mainly, in trying to solve the problem of resistance that pathogenic organisms acquire to conventional drugs.
José Rodrigues do Carmo Neto, Rhanoica Oliveira Guerra, Juliana Reis Machado, Anielle Christine Almeida Silva, Marcos Vinicius da Silva   +4 more
openaire   +2 more sources

Antiprotozoal activities of symmetrical bishydroxamic acids

Bioorganic & Medicinal Chemistry, 2003
Symmetrical bishydroxamic acids along with their sodium salts containing an alkyl spacer between two aromatic rings were synthesized, and their antiparasitic activities were evaluated. Bishydroxamic acids were conveniently prepared from the alkylation of methyl 4-hydroxybenzoate with various dihalo-alkane, -alkene, and -ether followed by reaction with ...
Duy H, Hua, Masafumi, Tamura, Masahiro, Egi, Karl, Werbovetz, Dawn, Delfín, Manar, Salem, Peter K, Chiang   +6 more
openaire   +2 more sources

8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity

Journal of Natural Products, 2012
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastigotes, and Trypanosoma brucei brucei bloodstream forms.
Endeshaw, Molla, Zhu, Xiaohua, He, Shanshan, Pandharkar, Trupti, Cason, Emily, Mahasenan, Kiran V., Agarwal, Hitesh, Li, Chenglong, Munde, Manoj, Wilson, W. David, Bahar, Mark, Doskotch, Raymond W., Kinghorn, A. Douglas, Kaiser, Marcel, Brun, Reto, Drew, Mark E., Werbovetz, Karl A.   +16 more
openaire   +4 more sources

Antiprotozoal activity of proton-pump inhibitors

Bioorganic & Medicinal Chemistry Letters, 2011
Parasitic diseases are still a major health problem in developing countries. In our effort to find new antiparasitic agents, in this Letter we report the in vitro antiprotozoal activity of omeprazole, lansoprazole, rabeprazole and pantoprazole against Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Molecular modeling studies were
Jaime, Pérez-Villanueva, Antonio, Romo-Mancillas, Alicia, Hernández-Campos, Lilián, Yépez-Mulia, Francisco, Hernández-Luis, Rafael, Castillo   +5 more
openaire   +2 more sources

Antiprotozoal activity of chloroquinoline based chalcones

European Journal of Medicinal Chemistry, 2011
A new series of chloroquinoline based chalcones were synthesized and evaluated for in vitro antiamoebic and antimalarial activities. The results showed that out of fifteen compounds, four were found to be more active against the Entamoeba histolytica; while one compound was moderatively active compared to the standard drug metronidazole (IC50=1.46 μM).
Faisal, Hayat, Emma, Moseley, Attar, Salahuddin, Robyn L, Van Zyl, Amir, Azam   +4 more
openaire   +2 more sources

Antiprotozoal Activity and DNA Binding of Dicationic Acridones

Journal of Medicinal Chemistry, 2015
Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity indices >1000. Compounds 1b, 3a, and 3b were as potent as the reference drug melarsoprol in this assay.
Montalvo-Quirós, Sandra, Taladriz-Sender, Andrea, Kaiser, Marcel, Dardonville, Christophe   +3 more
openaire   +5 more sources

Synthesis and Antiprotozoal Activity of Cationic 2-Phenylbenzofurans

Journal of Medicinal Chemistry, 2008
A series of cationically substituted 2-phenylbenzofurans 1- 49 have been synthesized, and their in vitro antiprotozoal properties against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, as well as cytotoxicity against mammalian cells, have been evaluated.
Stanislav A, Bakunov, Svetlana M, Bakunova, Tanja, Wenzler, Todd, Barszcz, Karl A, Werbovetz, Reto, Brun, Richard R, Tidwell   +6 more
openaire   +2 more sources