Results 1 to 10 of about 24,129 (266)

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Molecules, 2021
Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products.
Valery M Dembitsky, Nick Savidov, V V Poroikov   +2 more
exaly   +4 more sources

Antiprotozoal peptide prediction using machine learning with effective feature selection techniques [PDF]

Heliyon
Background: Protozoal pathogens pose a considerable threat, leading to notable mortality rates and the ongoing challenge of developing resistance to drugs. This situation underscores the urgent need for alternative therapeutic approaches.
Neha Periwal, Pooja Arora, Ananya Thakur, Lakshay Agrawal, Yash Goyal, Anand S. Rathore, Harsimrat Singh Anand, Baljeet Kaur, Vikas Sood   +8 more
doaj   +3 more sources

The Potassium Channel Blocker β-Bungarotoxin from the Krait Bungarus multicinctus Venom Manifests Antiprotozoal Activity

Biomedicines, 2023
Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression.
Alexey V. Osipov, Elena G. Cheremnykh, Rustam H. Ziganshin, Vladislav G. Starkov, Trang Thuy Thi Nguyen, Khoa Cuu Nguyen, Dung Tien Le, Anh Ngoc Hoang, Victor I. Tsetlin, Yuri N. Utkin   +9 more
doaj   +2 more sources

Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach

Scientific Reports, 2022
Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen, Evren Tileklioglu, Edna Bode, Harun Cimen, Hatice Ertabaklar, Derya Ulug, Sema Ertug, Sebastian L. Wenski, Mustapha Touray, Canan Hazir, Duygu Kaya Bilecenoglu, Ibrahim Yildiz, Helge B. Bode, Selcuk Hazir   +13 more
doaj   +2 more sources

Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review

Pathogens, 2021
Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Zainab U. Abdullahi, Salihu S. Musa, Daihai He, Umar M. Bello   +3 more
doaj   +2 more sources

Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives

Molecules, 2021
Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar, Lilián Yépez-Mulia, Miguel Cortés-Gines, Jacobo David Aguilera-Perdomo, Edgar A. Quintana-Salazar, Kevin Samael Olascoaga Del Angel, Francisco Cortés-Benítez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche, Jaime Pérez-Villanueva   +9 more
doaj   +2 more sources

Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata

Marine Drugs, 2017
Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic centers isolated from the Irish brown alga Bifurcaria ...
Vangelis Smyrniotopoulos, Christian Merten, Marcel Kaiser   +2 more
exaly   +3 more sources

Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions

Molecules, 2017
The biological activity of organic peroxides is usually associated with the antimalarial properties of artemisinin and its derivatives. However, the analysis of published data indicates that organic peroxides exhibit a variety of biological activity ...
Vera A Vil', Alexey Ilovaisky, Ivan A Yaremenko   +2 more
exaly   +3 more sources

Review Marine Pharmacology in 2018: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action.

Pharmacological Research, 2022
The 2018 marine pharmacology literature review represents a continuation of the previous 11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during 2018 was performed by investigators in 44 countries and contributed novel ...
A. Mayer, Marsha L. Pierce, Katelyn Howe, Abimael D Rodríguez, O. Taglialatela‐Scafati, Fumiaki Nakamura, N. Fusetani   +6 more
semanticscholar   +1 more source

Novel Formula of Antiprotozoal Mixtures

Antibiotics, 2022
Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński, Jacek Łyczko, Henryk Różański, Antoni Szumny   +3 more
doaj   +1 more source