Results 21 to 30 of about 10,060 (179)

Generation of Aurachin Derivatives by Whole-Cell Biotransformation and Evaluation of Their Antiprotozoal Properties

Molecules, 2023
The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D inhibits other parasitic protozoa as well.
Sebastian Kruth, Cindy J.-M. Zimmermann, Katharina Kuhr, Wolf Hiller, Stephan Lütz, Jörg Pietruszka, Marcel Kaiser, Markus Nett   +7 more
doaj   +1 more source

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

Molecules, 2014
Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively.
Elver Otero, Sebastián Vergara, Sara M. Robledo, Wilson Cardona, Miguel Carda, Ivan D. Vélez, Carlos Rojas, Felipe Otálvaro   +7 more
doaj   +1 more source

In Vitro Evaluation of Antiprotozoal Properties, Cytotoxicity Effect and Anticancer Activity of New Essential-Oil Based Phytoncide Mixtures

Molecules, 2023
Protozoa, in both humans and animals, are one of the leading causes of disease. International programmes introduced in many countries have helped reduce the incidence of disease. However, it has recently become increasingly difficult to achieve the goals
Hubert Iwiński, Henryk Różański, Natalia Pachura, Aleksandra Wojciechowska, Tomasz Gębarowski, Antoni Szumny   +5 more
doaj   +1 more source

Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr.

Molecules, 2020
The rationale inspiring the discovery of lead compounds for the treatment of human parasitic protozoan diseases from natural sources is the well-established use of medicinal plants in various systems of traditional medicine.
Claudio Frezza, Alessandro Venditti, Armandodoriano Bianco, Mauro Serafini, Massimo Pitorri, Fabio Sciubba, Maria Enrica Di Cocco, Eleonora Spinozzi, Loredana Cappellacci, Anders Hofer, Filippo Maggi, Riccardo Petrelli   +11 more
doaj   +1 more source

Anti-coccidial activity of the ethanol extract of Tribulus terrestris fruits on Eimeria tenella

Laboratory Animal Research, 2018
Anti-coccidial effects of the fruits of Tribulus terrestris (Tribuli fructus) ethanol extract (TTE) were studied with animal experiment following per oral administration with Eimeria (E.) tenella.
Sunhwa Hong, Mi-Na Moon, Eun-Kyung Im, Jum-Soon Won, Ji-Hyun Yoo, Okjin Kim   +5 more
doaj   +1 more source

Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes

Antibiotics, 2023
Aurachins are farnesylated quinolone alkaloids of bacterial origin and excellent inhibitors of the respiratory chain in pro- and eukaryotes. Therefore, they have become important tool compounds for the investigation of electron transport processes and ...
Sebastian Kruth, Markus Nett
doaj   +1 more source

The Potassium Channel Blocker β-Bungarotoxin from the Krait Bungarus multicinctus Venom Manifests Antiprotozoal Activity

Biomedicines, 2023
Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression.
Alexey V. Osipov, Elena G. Cheremnykh, Rustam H. Ziganshin, Vladislav G. Starkov, Trang Thuy Thi Nguyen, Khoa Cuu Nguyen, Dung Tien Le, Anh Ngoc Hoang, Victor I. Tsetlin, Yuri N. Utkin   +9 more
doaj   +1 more source

Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi

Molecules, 2013
In order to determine the in vivo activity against the protozoan Trypanosoma cruzi, two doses (50 and 75 mg/kg) of a chloroform extract of Carica papaya seeds were evaluated compared with a control group of allopurinol.
Karla Y. Acosta-Viana, Eugenia Guzman-Marín, Salud Perez-Gutiérrez, Antonio Ortega-Pacheco, Matilde Jiménez-Coello   +4 more
doaj   +1 more source

A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole

Marine Drugs, 2014
The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products.
Jan Tebben, Cherie Motti, Dianne Tapiolas, Peter Thomas-Hall, Tilmann Harder   +4 more
doaj   +1 more source

Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhodesiense

Molecules
Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free.
Nina Vahekeni, Théo Brillatz, Marjan Rahmaty, Monica Cal, Sonja Keller-Maerki, Romina Rocchetti, Marcel Kaiser, Sibylle Sax, Kevin Mattli, Evelyn Wolfram, Laurence Marcourt, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pascal Mäser   +13 more
doaj   +1 more source