Results 1 to 10 of about 6,856 (183)

Cytotoxic and Antileishmanial Effects of the Monoterpene β-Ocimene

Pharmaceuticals, 2023
Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions of the globe. The currently available drugs present serious problems such as high toxicity, costs, and the emergence of drug resistance. This
Jefferson Almeida Rocha, Daniel Dias Rufino Arcanjo, Alyne Rodrigues DE ARAUJO   +2 more
exaly   +3 more sources

7-Prenyloxycoumarins as Promising Antileishmanial Agents: In Vitro, In Vivo, and In Silico Evaluation Against Leishmania amazonensis [PDF]

Pharmaceuticals
Background/Objectives: Leishmaniasis remains a major neglected tropical disease, and current chemotherapeutic options are limited by toxicity and resistance in Leishmania species, including L. amazonensis.
Dirlei Nico, Daniel Clemente de Moraes, Anna Claudia Silva, Igor Nunes Taveira, Yasmin da Silva Fontes, Rosangela Sabbatini Capella Lopes, Cláudio Cerqueira Lopes, Antonio Ferreira-Pereira   +7 more
doaj   +2 more sources

Sterol Endoperoxides and Their Antileishmanial Effects: Influence on Viability, Oxygen Metabolism and Sterol Synthesis [PDF]

Molecules
Leishmaniasis is a global health issue, especially in tropical and subtropical areas, with treatment challenges due to the development of resistance to current drugs. This has prompted the search for new antileishmanial compounds.
Deblina Sarkar, Azra Aleta, Moris Ahmetašević, Mira Tosin, Laura Machin, Elisabeth Schrödl, Markus Bacher, Thomas Rosenau, Lianet Monzote, Katrin Staniek, Mitali Chatterjee, Lars Gille   +11 more
doaj   +2 more sources

Structure–Activity Relationship Analysis of Flavonoids Isolated from the Leaves of Erythroxylum rimosum O. E. Schulz [PDF]

Molecules
The flavonoids constitute a class of secondary metabolites distributed in plants, occurring in free form (aglycone) or conjugated sugars (glycosides), and are notable for their recognized pharmacological potential.
Ivana P. dos Santos, Maria Eduarda V. Costa, Geovana A. de Oliveira, Francisnaira S. Santos, Débora O. S. Vitória, Robson Almeida Silva, Janaina M. C. do Vale, Gildeon S. Marques, Ademir Evangelista do Vale, Milena Botelho Pereira Soares, Taise de A. Araújo, André Braga Teles, Elisalva Teixeira Guimarães, Erika Maria de Oliveira Ribeiro   +13 more
doaj   +2 more sources

Antileishmanial and antibacterial activities of biologically synthesized silver nanoparticles using Alcea rosea extract (AR-AgNPs) [PDF]

Journal of Water and Environmental Nanotechnology, 2021
Recent developments in nanotechnology lead to draw scientist's interest in green synthesis nanoparticles because of their importance in all fields of sciences.
Zahra Hashemi, Mina Shirzadi-Ahoodashti, mohammad ali Ebrahimzadeh   +2 more
doaj   +1 more source

Isopropyl Gallate, a Gallic Acid Derivative: In Silico and In Vitro Investigation of Its Effects on Leishmania major

Pharmaceutics, 2022
Isopropyl gallate (IPG) is a polyphenol obtained from alterations in the gallic acid molecule via acid catalysis with previously reported leishmanicidal and trypanocidal activities.
Danielly Silva de Melo, José Arimatéa de Oliveira Nery Neto, Maisa de Sousa dos Santos, Vinícius Duarte Pimentel, Rita de Cássia Viana Carvalho, Valéria Carlos de Sousa, Ruy Gabriel Costa Sousa, Lázaro Gomes do Nascimento, Michel Muálem de Moraes Alves, Daniel Dias Rufino Arcanjo, Damião Pergentino de Sousa, Fernando Aécio de Amorim Carvalho   +11 more
doaj   +1 more source

Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Microbiology Spectrum, 2022
Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite Leishmania species with a wide range of clinical manifestations.
Hannah N. Corman, Jessica N. Ross, Francisco R. Fields, Douglas A. Shoue, Mary Ann McDowell, Shaun W. Lee   +5 more
doaj   +1 more source

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

Metabolites, 2023
Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical composition of
Yuri Nascimento Fróes, João Guilherme Nantes Araújo, Joyce Resende dos Santos Gonçalves, Milena de Jesus Marinho Garcia de Oliveira, Gustavo Oliveira Everton, Victor Elias Mouchrek Filho, Maria Raimunda Chagas Silva, Luís Douglas Miranda Silva, Lucilene Amorim Silva, Lídio Gonçalves Lima Neto, Renata Mondêgo de Oliveira, Mylena Andréa Oliveira Torres, Luís Cláudio Nascimento da Silva, Alberto Jorge Oliveira Lopes, Amanda Silva dos Santos Aliança, Cláudia Quintino da Rocha, Joicy Cortez de Sá Sousa   +16 more
doaj   +1 more source

Antileishmanial activity of chlorpromazine [PDF]

Antimicrobial Agents and Chemotherapy, 1984
The antiprotozoal activity of chlorpromazine against the pathogenic protozoan Leishmania donovani, in both its amastigote and promastigote stages, was characterized. Chlorpromazine at concentrations greater than or equal to 3.12 micrograms/ml (9.8 X 10(-6) M) produced a significant reduction in viable promastigotes.
R D, Pearson, A A, Manian, D, Hall, J L, Harcus, E L, Hewlett   +4 more
openaire   +2 more sources

Antileishmanial Effect of Allopurinol [PDF]

Antimicrobial Agents and Chemotherapy, 1974
Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of ...
M A, Pfaller, J J, Marr
openaire   +2 more sources