Results 21 to 30 of about 6,856 (183)

Antileishmanial Activity of the Terpene Nerolidol [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACTThe activity of nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs, was evaluated againstLeishmaniaspecies. Nerolidol inhibited the growth ofLeishmania amazonensis,L. braziliensis, andL.
Denise C, Arruda, Fabio Luiz, D'Alexandri, Alejandro M, Katzin, Silvia R B, Uliana   +3 more
openaire   +2 more sources

Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative

Molecules, 2013
Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of ...
Louis Maes, Mahmoud H. Assaf, KamalEldin H. El Tahir, Mohamed Farag, Adnan J. Al-Rehaily, Omer A. Basudan, Ramzi A. Mothana, Nawal M. Al-Musayeib, Shaza M. Al-Massarani, Ali A. El Gamal   +9 more
doaj   +1 more source

New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia

Molecules, 2014
Phytochemical investigation of the methanolic extract of Tagetes minuta L. (Asteraceae) leaves resulted in the isolation and identification of two new compounds: 5-methyl-2,2',5',2'',5'',2''',5''',2''''-quinquethiophene (1) and quercetagetin-6-O-(6-O ...
Nawal M. Al-Musayeib, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Samir A. Ross   +3 more
doaj   +1 more source

Antileishmanial activity of a formulation of 2-n-propylquinoline by oral route in mice model

Parasite, 2011
2-n-propylquinoline is presently a drug-candidate for the treatment of visceral leishmaniosis in pre-clinical development. As this compound is in an oily state, it needs to be formulated and the objectives of this study are: to prepare a formulation; to ...
Campos Vieira N., Vacus J., Fournet A., Baudouin R., Bories C., Séon-Méniel B., Figadère B., Loiseau P.M.   +7 more
doaj   +1 more source

Antileishmanial activity of lapachol analogues [PDF]

Memórias do Instituto Oswaldo Cruz, 2004
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis.
Nadja M. F. Lima, Clariane S. Correia, Leonor L. Leon, Gérzia M. C. Machado, Maria de Fátima Madeira, Antônio Euzébio G. Santana, Marília O. F. Goulart   +6 more
openaire   +4 more sources

Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds

Anais da Academia Brasileira de Ciências, 2012
In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities.
Rodrigo L. Fabri, Elaine S. Coimbra, Ana C. Almeida, Ezequias P. Siqueira, Tânia M.A. Alves, Carlos L. Zani, Elita Scio   +6 more
doaj   +1 more source

Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated from Hypericum afrum Lam.: Phytochemistry, In Vitro Testing and Modeling Studies

Molecules, 2021
The in vitro activity of L. donovani (promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells) and T. brucei, from the fractions obtained from the hydroalcoholic extract of the aerial part of Hypericum afrum and the isolated ...
Farida Larit, Khaled M. Elokely, Manal A. Nael, Samira Benyahia, Francisco León, Stephen J. Cutler, Mohammed M. Ghoneim   +6 more
doaj   +1 more source

Assessment of the in Vitro Antiprotozoal and Cytotoxic Potential of 20 Selected Medicinal Plants from the Island of Soqotra

Molecules, 2012
Malaria, leishmaniasis and human African trypanosomiasis continue to be major public health problems in need of new and more effective drugs. The aim of this study was to evaluate in vitro antiprotozoal activity of twenty endemic medicinal plants ...
Louis Maes, Paul Cos, An Matheeussen, Nawal M. Al-Musayeib, Ramzi A. Mothana   +4 more
doaj   +1 more source

Developments in Diagnosis and Antileishmanial Drugs [PDF]

Interdisciplinary Perspectives on Infectious Diseases, 2012
Leishmaniasis ranks the third in disease burden in disability-adjusted life years caused by neglected tropical diseases and is the second cause of parasite-related deaths after malaria; but for a variety of reasons, it is not receiving the attention that would be justified seeing its importance.
Prachi Bhargava, Rajni Singh
openaire   +3 more sources

In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

Molecules, 2013
Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–
Louis Maes, Shaza M. Al-Massarani, Nawal M. Al Musayeib, Ramzi A. Mothana, Ali A. El Gamal   +4 more
doaj   +1 more source