Results 11 to 20 of about 6,856 (183)
Frontiers in Plant Science, 2023 We report the chemical composition of the crude leaf extracts obtained from Stizophyllum perforatum (Cham.) Miers (Bignoniaceae), a simple high-performance liquid chromatography–diode array detection (HPLC-DAD) method based on mangiferin as an internal ...
Osvaine Junior Alvarenga Alves +11 more
doaj +1 more source
Toxics, 2023 Metallic nanoparticles have received a significant amount of reflection over a period of time, attributed to their electronic, specific surface area, and surface atom properties. The biogenic synthesis of iron oxide nanoparticles (FeONPs) is demonstrated
Lubna Anjum Minhas +8 more
doaj +1 more source
Berberine derivatives as antileishmanial drugs [PDF]
Antimicrobial Agents and Chemotherapy, 1990 Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L.
J L, Vennerstrom +4 more
openaire +2 more sources
Effect of 3-Carene and the Micellar Formulation on Leishmania (Leishmania) amazonensis
Tropical Medicine and Infectious Disease, 2023 Leishmaniases are neglected tropical diseases caused by obligate intracellular protozoa of the genus Leishmania. The drugs used in treatment have a high financial cost, a long treatment time, high toxicity, and variable efficacy.
Audrey Rouse Soares Tavares Silva +10 more
doaj +1 more source
Immunomodulatory effects of antileishmanial drugs [PDF]
Journal of Antimicrobial Chemotherapy, 2013 The commonly used antileishmanial drugs are sodium antimony gluconate (SAG), amphotericin B, miltefosine and paromomycin. There are a number of reports that antileishmanial drugs show immunomodulatory properties. Here, we attempt to understand how the innate arm of the immune system is modulated in response to these antileishmanial drugs.BALB/c ...
Moumita, Ghosh +2 more
openaire +2 more sources
In Vitro Antileishmanial Activity of Nicotinamide [PDF]
Antimicrobial Agents and Chemotherapy, 2005 ABSTRACT Our study represents the first report demonstrating the antileishmanial activity of nicotinamide (NAm), a form of vitamin B 3 . A 5 mM concentration of NAm significantly inhibited the intracellular growth of Leishmania amastigotes and the NAD-dependent deacetylase activity ...
D, Sereno +4 more
openaire +2 more sources
Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress [PDF]
Memorias do Instituto Oswaldo Cruz, 2022 Despite the increasing number of manuscripts describing potential alternative antileishmanial compounds, little is advancing on translating these knowledges to new products to treat leishmaniasis.
Rubens Lima do Monte Neto +5 more
doaj +1 more source
Arylthiosemicarbazones as antileishmanial agents
European Journal of Medicinal Chemistry, 2016 Based on a screening process, we targeted substituted thiosemicarbazone as potential antileishmanial agents. Our objective was to identify the key structural elements contributing to the anti-parasite activity that might be used for development of effective drugs.
Manzano, José Ignacio +6 more
openaire +4 more sources
Antileishmanial activity of polycyclic derivatives [PDF]
Parasite, 2005 33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line. The reference molecules used in the assays were amphotericin B and pentamidine.
Sarciron, M.E. +8 more
openaire +5 more sources
Screening of six medicinal plant species for antileishmanial activity
Acta Pharmaceutica, 2021 This study is aimed to investigate the in vitro anti-leishmanial activity of ethanolic, aqueous or dichloromethane extracts of leaves, flowers, fruits or roots, of six medicinal plant species, namely, Nectandra megapotamica, Brunfelsia uniflora ...
Ferreira Fabiana Borges Padilha +8 more
doaj +1 more source