Results 31 to 40 of about 10,060 (179)
Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives
Molecules, 2021 Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar +9 more
doaj +1 more source
Veterinary Ophthalmology, Volume 28, Issue 2, Page 438-447, March 2025.Abstract Objective This retrospective study evaluates the efficacy of povidone‐iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Animals Studied Horses that underwent routine ophthalmic surgery and procedures.
Anna Farkas +4 more
wiley +1 more source
Molecules, 2017 Parasitic diseases are a public health problem affecting millions of people worldwide. One of the scaffolds used in several drugs for the treatment of parasitic diseases is the benzimidazole moiety, a heterocyclic aromatic compound.
Emanuel Hernández-Núñez +5 more
doaj +1 more source
GENOMIC, PROTEOMIC AND MOLECULAR MODEL ANALYSES OF TMP KINASE FROM SOME BLOODPARASITIC PROTOZOA. ONE-STEP FORWARD IN DEVELOPMENT OF BROAD SPECTRUM ANTIPROTOZOAL DRUGS [PDF]
Kafrelsheikh Veterinary Medical Journal, 2009 We had introduced TMP kinase as a new hopeful antiprotozoal drugtarget. We provided theoretical model for the eligibility of TMP kinasefrom Plasmodium falciparum as a new drug target and we confirmedour assumption by experimental trials based on ...
Yukio Kitade, Mahmoud Kandeel
doaj +1 more source
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
Animal Research and One Health, Volume 4, Issue 3, Page 302-313, August 2026.Activo Liquid and Halquinol inhibit Salmonella and Escherichia coli in culture media. Activo Liquid exhibits bactericidal action, whereas HA is bacteriostatic, and their combination results in positive or indifferent interactions. This combination effectively inhibits E. coli throughout digestion simulation, thus reducing the required concentrations of
Alberto Gonçalves Evangelista +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2937-2948, August 2026.Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber +7 more
wiley +1 more source
Scientific Reports, 2022 Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen +13 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas +9 more
wiley +1 more source
Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone
eFood, Volume 7, Issue 4, August 2026.Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu +4 more
wiley +1 more source