Results 31 to 40 of about 17,418 (254)
Analysis of Giardia lamblia Nucleolus as Drug Target: A Review
Pharmaceuticals, 2023 Giardia lamblia (G. lamblia) is the main causative agent of diarrhea worldwide, affecting children and adults alike; in the former, it can be lethal, and in the latter a strong cause of morbidity.
Carlos Gaona-López +4 more
doaj +1 more source
Pharmacokinetics of Diclazuril in the Plasma and Cerebrospinal Fluid of Healthy Adult Horses After a Single Oral Dose Administered as a Pelleted Topdressing. [PDF]
J Vet Pharmacol TherABSTRACT Equine protozoal myeloencephalitis can cause acute infections with rapid onset of neurologic signs, necessitating immediate empiric therapy with antiprotozoal medication. The objective of the study was to identify when concentrations of diclazuril reached the MIC of Sarcocystis neurona in CSF (1 ng/mL) of healthy adult horses after a single ...
Treece EJ +7 more
europepmc +2 more sources
Antiprotozoal drugs: challenges and opportunities
Expert Opinion on Therapeutic Patents, 2023 Protozoans are widespread organisms in most habitats worldwide, being a paraphyletic group with an intricate evolutionary history [1,2]. There is a multitude of phyla, genera, and protozoan species, many of which ecologically and industrially relevant ...
C. Supuran
semanticscholar +1 more source
Bioactive Essential Oils from Cuban Plants: An Inspiration to Drug Development
Plants, 2021 Aromatic plants and essential oils are important agents as complementary and alternative medicines in many cultures and geographical locations. In this review, a literature search on essential oils from Cuba, their chemical compositions, and their ...
Lianet Monzote +4 more
doaj +1 more source
Veterinary Sciences, 2022 To evaluate the anticoccidial effect of the Hura crepitans seed, 21 cross-breed lambs, 23 ± 3 kg live weight (PV) and 70 ± 6 days old, were used. Animals were housed individually in raised wire-mesh pens, with individual water troughs and feeders.
Martha-Yanira Velazquez-González +6 more
doaj +1 more source
Marine Drugs, 2021 The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported ...
A. Mayer +5 more
semanticscholar +1 more source
Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]
Chem BiodiversDicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS +9 more
europepmc +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano +13 more
semanticscholar +1 more source
Marine Drugs, 2021 The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules.
Nayara Sousa da Silva +10 more
doaj +1 more source
Molecules, 2022 Three species from the Eryngium L. genus—E. campestre, E. maritimum, and E. planum, plants with a rich chemical composition, were selected for phytochemical and biological studies.
M. Kikowska +6 more
semanticscholar +1 more source