Results 41 to 50 of about 10,060 (179)

Virtual Screening of Bacteriocins From Lactic Acid Bacteria Against Monkeypox DNA Polymerase: Sakacin P and Mundticin KS Emerge as Promising Candidates

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study employs an in silico virtual screening workflow to evaluate lactic acid bacteria (LAB)‐derived bacteriocins as potential inhibitors of the monkeypox virus DNA polymerase (MPDP). Protein‐peptide docking simulations using the HADDOCK platform revealed that Sakacin P and Mundticin KS possess the highest binding affinities for the MPDP target ...
Melisa Z. Karaman, Karan Goel, Fernando Berton Zanchi, Aykut Ozdarendeli, Somdutt Mujwar, Ahmet E. Yetiman, Ozkan Fidan   +6 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Endoperoxides: Highly Oxygenated Terpenoids with Anticancer and Antiprotozoal Activities

Compounds
Endoperoxides constitute a distinctive class of highly oxygenated terpenoids defined by the presence of a cyclic peroxide (–O–O–) bond, a structural motif responsible for their pronounced chemical reactivity and diverse biological effects.
Valery M. Dembitsky, Alexander O. Terent’ev   +1 more
doaj   +1 more source

Antiprotozoal Drug Handling and Management Practices in Asella District, Central Oromia, Ethiopia

Veterinary Medicine International, 2021
Background and Methods. Protozoal infections such as dourine caused by trypanosomes are found to be a threat to the life and productivity of the equine population. Inappropriate drug use is a problem of the whole world; however, the degree of the problem
Ashenafi Ababu, Dereje Endashaw, Haben Fesseha, Mesfin Mathewos   +3 more
doaj   +1 more source

Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia, Valentina D'Onghia, Valentina Semeraro, Esposito Susanna, Maria Elisabeth Street   +4 more
wiley   +1 more source

Exploring the Factors Influencing the Non‐Prescription Use of Medication in Bangladesh: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Use of non‐prescription drugs is a significant health concern for the population in Bangladesh. The ease of access to medicines, the high price of healthcare and lack of information on how to take the drugs properly promote such a practice.
Sumaia Rahman, S. M. Mahadi Hasan, Md. Omar Faruk, Md. Aminul Islam Nur, Mst. Hajera Khatun   +4 more
wiley   +1 more source

In vitro antimicrobial assessment of Cuban propolis extracts

Memorias do Instituto Oswaldo Cruz, 2012
Propolis is a resinous mixture of different plant exudates collected by honeybees. Currently, propolis is widely used as a food supplement and in folk medicine.
Lianet Monzote, Osmany Cuesta-Rubio, Mercedes Campo Fernandez, Ingrid Márquez Hernandez, Jorge Fraga, Kleich Pérez, Monique Kerstens, Louis Maes, Paul Cos   +8 more
doaj   +1 more source

Clinical and Diagnostic Considerations in Laryngeal Leishmaniasis: A Systematic Review

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective Laryngeal leishmaniasis is a rare, insidious manifestation of Leishmania infection with potential for life‐threatening complications. Awareness is critical for efficient and timely diagnosis. This systematic review of laryngeal leishmaniasis focuses on presentation, treatment, and the role of serological studies in the work up of ...
Joseph Celidonio, Nicholas Hamilton, Alexandra Filipkowski, Raj Malhotra, Samantha Shave, Myat E. Mon, Kenneth Yan, Rachel Kaye   +7 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source