Results 51 to 60 of about 10,060 (179)

Antimalarial activity and toxicity of Garcinia mangostana L. pericarp extracts and major xanthones: A systematic review of in vitro and in vivo studies [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Malaria morbidity remains high, and resistance to antimalarial drugs and diagnostics continues to expand. Aims: To systematically evaluate the in vitro/in vivo antimalarial efficacy and toxicity of Garcinia mangostana L. pericarp extracts (MP)
Joanne T. Winata, Ahmad K. Nugroho, Yosi B. Murti, Arief Nurrochmad   +3 more
doaj   +1 more source

Evaluation of the Utilization Pattern of Veterinary Drugs in Selected Veterinary Clinics of Mekelle City, Tigray, Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Veterinary drug utilization patterns were assessed in three veterinary clinics in Mekelle City, Ethiopia. Antimicrobials, particularly oxytetracycline, constitute the majority of prescriptions, followed by anthelmintics. Drug prescribing frequently relies on tentative diagnosis rather than evidence‐based diagnostic procedures.
Helen Hagos, Mebrahtu Weldegebriel, Hagazi Fantay, Haftom Yirga Tsegay   +3 more
wiley   +1 more source

Blood Protozoan Infection Disrupts Ovarian Follicular Development in Dairy Cattle: A Mechanistic Link to Reproductive Failure

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Subclinical haemoprotozoan infection disrupts RBC integrity, and that leads to decreased Hb level and excess free iron in plasma. That subsequently impairs ovarian follicular development and thereby builds up a mechanistic link to reproductive failure in dairy cattle.
Most. Mousumi Akter, Md. Sadequl Islam, Md. Ashraful Islam, Md. Mahmudul Hasan, Rakibul Islam, Md. Mominul Islam, Md. Gausur Rahman, Md. Shafiqul Islam, Anup Kumar Talukder, Md. Bazlar Rashid   +9 more
wiley   +1 more source

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Synthesis of Oxazolyl‐Piperidines Bearing a Quaternary Stereocenter Through a Multicomponent Reaction Involving α‐Isocyanoacetates and Piperidones

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare, Gilles Argouarch, Nicolas Gouault, Claudia Lalli   +3 more
wiley   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

The Mediterranean Red Alga Asparagopsis: A Source of Compounds against Leishmania

Marine Drugs, 2009
Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds.
Marina Morabito, Mark T. Hamann, Laura Tedone, Giuseppa Genovese   +3 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Chemical Constituents and Pharmacology properties of Aristolochia triangularis: a south brazilian highly-consumed botanical with multiple bioactivities

Anais da Academia Brasileira de Ciências
: Aristolochia triangularis Cham., is one of the most frequently used medicinal plant in Southern Brazil. Preparations containing the leaves and/or stems are traditionally used as anti-inflammatory, diuretic, as well as antidote against snakebites.
SIMONE Q. OLIVEIRA, JADEL M. KRATZ, VITOR C. CHAVES, TATIANA R. GUIMARÃES, DANIELLE T.M. COSTA, SAPFO DIMITRAKOUDI, ARGYRO VONTZALIDOU, SÉRGIO A.L. BORDIGNON, CESAR P. SIMIONATO, MÁRIO STEINDEL, FLÁVIO H. REGINATTO, CLÁUDIA M.O. SIMÕES, ELOIR P. SCHENKEL   +12 more
doaj   +1 more source

Antiprotozoal Activity against Entamoeba histolytica of Plants Used in Northeast Mexican Traditional Medicine. Bioactive Compounds from Lippia graveolens and Ruta chalepensis

Molecules, 2014
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries.
Ramiro Quintanilla-Licea, Benito David Mata-Cárdenas, Javier Vargas-Villarreal, Aldo Fabio Bazaldúa-Rodríguez, Isvar Kavimngeles-Hernández, Jesús Norberto Garza-González, Magda Elizabeth Hernández-García   +6 more
doaj   +1 more source