Results 11 to 20 of about 17,418 (254)

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Molecules, 2021
Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products.
Vladimir Poroikov, Ekaterina V Ermolenko, Nick Savidov   +2 more
exaly   +5 more sources

Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review

Pathogens, 2021
Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Salihu S. Musa, Umar M Bello, Daihai He
exaly   +4 more sources

Antiprotozoal peptide prediction using machine learning with effective feature selection techniques

Heliyon
Background: Protozoal pathogens pose a considerable threat, leading to notable mortality rates and the ongoing challenge of developing resistance to drugs. This situation underscores the urgent need for alternative therapeutic approaches.
Neha Periwal, Pooja Arora, Ananya Thakur, Lakshay Agrawal, Yash Goyal, Anand S. Rathore, Harsimrat Singh Anand, Baljeet Kaur, Vikas Sood   +8 more
doaj   +3 more sources

Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives

Molecules, 2021
Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar, Lilián Yépez-Mulia, Miguel Cortés-Gines, Jacobo David Aguilera-Perdomo, Edgar A. Quintana-Salazar, Kevin Samael Olascoaga Del Angel, Francisco Cortés-Benítez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche, Jaime Pérez-Villanueva   +9 more
doaj   +3 more sources

Novel Formula of Antiprotozoal Mixtures

Antibiotics, 2022
Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński, Jacek Łyczko, Henryk Różański, Antoni Szumny   +3 more
doaj   +2 more sources

Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action [PDF]

Angewandte Chemie, 2021
Leucinostatin A is one of the most potent antiprotozoal compounds ever described, but little was known on structure–activity relationships (SAR).
M. Brand, Lei Wang, S. Agnello, S. Gazzola, F. M. Gall, Luka Raguž, M. Kaiser, Remo S. Schmidt, Amélie Ritschl, J. Jelk, A. Hemphill, P. Mäser, P. Bütikofer, Michael Adams, Rainer Riedl   +14 more
semanticscholar   +3 more sources

Antiprotozoal Nor-Triterpene Alkaloids from Buxus sempervirens L. [PDF]

Antibiotics, 2021
Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents.
Lara U. Szabó, M. Kaiser, P. Mäser, T. Schmidt   +3 more
semanticscholar   +2 more sources

Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach

Scientific Reports, 2022
Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen, Evren Tileklioglu, Edna Bode, Harun Cimen, Hatice Ertabaklar, Derya Ulug, Sema Ertug, Sebastian L. Wenski, Mustapha Touray, Canan Hazir, Duygu Kaya Bilecenoglu, Ibrahim Yildiz, Helge B. Bode, Selcuk Hazir   +13 more
doaj   +2 more sources

Identification of Steroidal Alkaloids with In Vitro Antiprotozoal Activity from Holarrhena pubescens Wall. ex G. Don [PDF]

Molecules
Human African Trypanosomiasis (HAT) and Malaria are serious infectious diseases endemic in tropical regions, caused by protozoan parasites, and necessitating an urgent development of new antiprotozoal drugs.
Justus Wambua Mukavi, Monica Cal, Marcel Kaiser, Pascal Mäser, Njogu M. Kimani, Leonidah Kerubo Omosa, Thomas J. Schmidt   +6 more
doaj   +2 more sources

Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions

Molecules, 2017
The biological activity of organic peroxides is usually associated with the antimalarial properties of artemisinin and its derivatives. However, the analysis of published data indicates that organic peroxides exhibit a variety of biological activity ...
Alexander O Terent'ev, Vera A Vil', Ivan A Yaremenko   +2 more
exaly   +3 more sources