Results 161 to 170 of about 7,779 (200)

Structure−Activity Study of Pentamidine Analogues as Antiprotozoal Agents

Journal of Medicinal Chemistry, 2009
Diamidine 1 (pentamidine) and 65 analogues (2-66) have been tested for in vitro antiprotozoal activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for cytotoxicity against mammalian cells. Dications 32, 64, and 66 exhibited antitrypanosomal potencies equal or greater than melarsoprol (IC(50) = 4 nM ...
Bakunova, S. M., Bakunov, S. A., Patrick, D. A., Kumar, E. V., Ohemeng, K. A., Bridges, A. S., Wenzler, T., Barszcz, T., Jones, S. K., Werbovetz, K. A., Brun, R., Tidwell, R. R.   +11 more
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ChemInform Abstract: Synthesis of Possible Antiprotozoal Agents.

Chemischer Informationsdienst, 1985
Abstract(Ia) wird auf dem angegebenen Weg in die Arylcarbonsäure (Ic) übergeführt, die wie ihre homologe Verbindung (Id) zu den cyclischen Ketonen (IIa) bzw. (IIb) cyclisiert wird.
B. R. SARKAR, D. GHOSH, B. C. PATHAK
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Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole

Bioorganic & Medicinal Chemistry, 2006
A series of naphthalene analogues of highly active benzimidazole diamidines were synthesized using sequential Stille and Suzuki coupling reactions for preparation of the bis-nitrile intermediates. All of the diamidines showed strong DNA affinities as judged by high DeltaTm values with poly(dA-dT).
Sarah, Chackal-Catoen, Yi, Miao, W David, Wilson, Tanja, Wenzler, Reto, Brun, David W, Boykin   +5 more
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Modes of Action of Antiprotozoal Agents

1986
There are relatively few antiprotozoal agents compared with the many antibiotics available for the treatment of bacterial infections. Similarities in host and eukaryotic parasite metabolism have made development of specific chemotherapeutic agents difficult and have necessitated the use of agents that often exhibit limited specificity for the parasite ...
Douglas L. Looker, J. Joseph Marr, Ronald L. Stotish   +2 more
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Antiprotozoal and Anthelmintic Agents

2011
Since combination chemotherapy is becoming normal practice in the management of parasitic disease there have been predictions of a vast array of potential interactions caused by drug classes sharing common routes of elimination. This chapter reviews the key interactions likely to occur or those that have been seen to occur when drugs are administered ...
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Tropical Plants as Sources of Antiprotozoal Agents

1993
Protozoa are the cause of a number of major diseases which spread massive misery and death, mainly throughout the tropical world. Malaria is the protozoal disease most feared by travellers to the tropics, but other protozoal diseases such as leishmaniasis, trypanosomiasis, amoebiasis and giardiasis cause havoc for many millions of people.
J. David Phillipson, Colin W. Wright, Geoffrey C. Kirby, David C. Warhurst   +3 more
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Inhibitors of Dihydrofolate Reductase as Antiprotozoal Agents

1983
The therapeutic potential of inhibitors of dihydrofolate reductase as selectively toxic agents was first realized in early studies involving laboratory species of the genus Plasmodium. These experiments were carried out initially with readily standardized infections of Plasmodium gallinaceum in chicks and P. berghei in mice.
openaire   +1 more source

Molecular imaging in oncology: Current impact and future directions

Ca-A Cancer Journal for Clinicians, 2022
Steven P Rowe, Martin G Pomper
exaly  

Antiprotozoal agents

2010
Simon L. Croft, Karin Seifert
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Antiparasitic/Antiprotozoal Agents

2017
V Ramesh, Kabir Sardana
openaire   +1 more source