Results 171 to 180 of about 14,028 (214)

Chemistry of Antiprotozoal Agents

1986
The search for agents useful for the prevention or cure of the protozoal diseases malaria and sleeping sickness was closely linked to the early development of medicinal chemistry (see Chapter 1). Unlike antibacterial agents, for which a few chemical structural classes exhibit a wide spectrum of biological activity, antiprotozoal activity exists in a ...
John C. Chabala, Max W. Miller
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New antiprotozoal agents: Their synthesis and biological evaluations

Bioorganic & Medicinal Chemistry Letters, 2013
Here we report identification of new lead compounds based on quinoline and indenoquinolines with variable side chains as antiprotozoal agents. Quinolines 32, 36 and 37 (Table 1) and indenoquinoline derivatives 14 and 23 (Table 2) inhibit the in vitro growth of the Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense subspecies and ...
Upadhayaya, Ram Shankar, Dixit, Shailesh S., Földesi, Andras, Chattopadhyaya, Jyoti   +3 more
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Histone Deacetylase: A Target for Antiproliferative and Antiprotozoal Agents

Current Medicinal Chemistry, 2001
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. It is well-established that in transcriptionally active chromatin, histones generally are hyperacetylated and ...
P T, Meinke, P, Liberator
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Assessing Antiprotozoal Agents

2009
Nitrogen metabolism in the rumen affects both the efficiency of ruminant production and the environmental impact of excreta from ruminant livestock production. Inefficient N retention by rumen microorganisms is compensated in production terms by feeding excessive amounts of dietary protein to the animal to meet required output levels.
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Antifungal, antiprotozoal and antiviral agents

1989
In addition to bacterial disease many infections are caused by fungi, viruses and protozoa. Chemotherapy of these infections has been somewhat neglected because of the difficulty in designing safe and selective agents, but in recent years chemical ingenuity has led to some major breakthroughs.
T. J. Franklin, G. A. Snow
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Structure−Activity Study of Pentamidine Analogues as Antiprotozoal Agents

Journal of Medicinal Chemistry, 2009
Diamidine 1 (pentamidine) and 65 analogues (2-66) have been tested for in vitro antiprotozoal activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for cytotoxicity against mammalian cells. Dications 32, 64, and 66 exhibited antitrypanosomal potencies equal or greater than melarsoprol (IC(50) = 4 nM ...
Bakunova, S. M., Bakunov, S. A., Patrick, D. A., Kumar, E. V., Ohemeng, K. A., Bridges, A. S., Wenzler, T., Barszcz, T., Jones, S. K., Werbovetz, K. A., Brun, R., Tidwell, R. R.   +11 more
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ChemInform Abstract: Synthesis of Possible Antiprotozoal Agents.

Chemischer Informationsdienst, 1985
Abstract(Ia) wird auf dem angegebenen Weg in die Arylcarbonsäure (Ic) übergeführt, die wie ihre homologe Verbindung (Id) zu den cyclischen Ketonen (IIa) bzw. (IIb) cyclisiert wird.
B. R. SARKAR, D. GHOSH, B. C. PATHAK
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Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole

Bioorganic & Medicinal Chemistry, 2006
A series of naphthalene analogues of highly active benzimidazole diamidines were synthesized using sequential Stille and Suzuki coupling reactions for preparation of the bis-nitrile intermediates. All of the diamidines showed strong DNA affinities as judged by high DeltaTm values with poly(dA-dT).
Sarah, Chackal-Catoen, Yi, Miao, W David, Wilson, Tanja, Wenzler, Reto, Brun, David W, Boykin   +5 more
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Modes of Action of Antiprotozoal Agents

1986
There are relatively few antiprotozoal agents compared with the many antibiotics available for the treatment of bacterial infections. Similarities in host and eukaryotic parasite metabolism have made development of specific chemotherapeutic agents difficult and have necessitated the use of agents that often exhibit limited specificity for the parasite ...
Douglas L. Looker, J. Joseph Marr, Ronald L. Stotish   +2 more
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Antiprotozoal and Anthelmintic Agents

2011
Since combination chemotherapy is becoming normal practice in the management of parasitic disease there have been predictions of a vast array of potential interactions caused by drug classes sharing common routes of elimination. This chapter reviews the key interactions likely to occur or those that have been seen to occur when drugs are administered ...
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