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Tropical Plants as Sources of Antiprotozoal Agents
1993Protozoa are the cause of a number of major diseases which spread massive misery and death, mainly throughout the tropical world. Malaria is the protozoal disease most feared by travellers to the tropics, but other protozoal diseases such as leishmaniasis, trypanosomiasis, amoebiasis and giardiasis cause havoc for many millions of people.
J. David Phillipson +3 more
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Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents
Bioorganic & Medicinal Chemistry Letters, 2006Compounds 10a (IC50 110 pM) and 21 (IC50 40 pM) are the most potent inhibitors of Eimeria tenella cGMP-dependent protein kinase activity reported to date and are efficacious in the in vivo antiparasitic assay when administered to chickens at 12.5 and 6.25 ppm levels in the feed.
Tesfaye, Biftu +21 more
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Inhibitors of Dihydrofolate Reductase as Antiprotozoal Agents
1983The therapeutic potential of inhibitors of dihydrofolate reductase as selectively toxic agents was first realized in early studies involving laboratory species of the genus Plasmodium. These experiments were carried out initially with readily standardized infections of Plasmodium gallinaceum in chicks and P. berghei in mice.
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HERB EXTRACTS AS POTENTIAL ANTIPROTOZOAL AGENTS
Acta Horticulturae, 1996C. D. McClure, Linda L. Nolan
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