Results 161 to 170 of about 14,028 (214)

Ethnomedicinal Evidence for Medicinal Plants of the Asteraceae Family Used by Tanzanians to Treat Various Ailments: A Review. [PDF]

Biomed Res Int
Kacholi DS.
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Antiprotozoal Agents from Plant Sources

Planta Medica, 1991
Protozoa are responsible for a number of serious tropical diseases including amoebiasis, leishmaniasis, malaria, and trypanosomiasis. New drugs are required for the treatment of these diseases and the potential of plants to produce new clinical agents is discussed.
J D, Phillipson, C W, Wright
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Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents

Current Medicinal Chemistry, 2021
Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year.
Antonio Moreno-Herrera, Sandra Cortez-Maya, Virgilio Bocanegra-Garcia, Bimal Krishna Banik, Gildardo Rivera   +4 more
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Tinidazole: A nitroimidazole antiprotozoal agent

Clinical Therapeutics, 2005
Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
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Saponins as Potential Antiprotozoal Agents

2021
The sphere of natural products is an abundant source for discovery of therapeutic drugs for the treatment of neglected parasitic diseases. Various classes of chemical substances displayed antiprotozoal activity, such as alkaloids, terpenoids, saponins, and flavonoids.
Ana Claudia F. Amaral, Aline de S. Ramos, José Luiz P. Ferreira, Maíra Martins H. de Almeida, Jefferson D. da Cruz, Danielle L. de Oliveira, Ana Clara B. Maria, Aimee A. de Oliveira, Igor A. Rodrigues, Jefferson R. de A. Silva   +9 more
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Antiprotozoal Agents: An Overview

Anti-Infective Agents in Medicinal Chemistry, 2009
The therapy of parasitic diseases has relied, until recently, on the use of a very limited number of drugs, most of them of low efficacy, leading to side effects and in certain cases with high toxicity. This review focuses on the chemother- apy to treat diseases caused by Trypanosoma cruzi (Chagas' disease), Trypanosoma b.
C. Graebin, F. Uchoa, L. Bernardes, V. Campo, I. Carvalho, V. Eifler-Lima   +5 more
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Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Bioorganic & Medicinal Chemistry, 2004
A series of biphenyl benzimidazoles diamidines 6a-i were synthesized from their respective diamidoximes, through the bis-O-acetoxyamidoxime followed by hydrogenation in glacial acetic acid/ethanol in the presence of Pd-C. The target compounds contain hydroxy and/or methoxy substituted 1,3-phenyl groups as the central spacer between the two amidino ...
Mohamed A, Ismail, Reto, Brun, Tanja, Wenzler, Farial A, Tanious, W David, Wilson, David W, Boykin   +5 more
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Antiprotozoal and Anthelmintic Agents

2018
Combination chemotherapy is commonly indicated for treatment of parasitic diseases and dictated by a requirement to combine the aim of effective chemotherapy with the wish to minimize emergence of drug resistance. Throughout the past few decades, the clinical pharmacokinetics and metabolism of many antiparasitic agents have been elucidated ...
Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom   +2 more
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ChemInform Abstract: New Antiprotozoal Agents.

Chemischer Informationsdienst, 1976
AbstractDie Nitro‐Derivate (IV), (V) und (VI) von Diimidazo‐ [1,2‐a; 2′,l ′‐c]pyrazin und Diimidazol [1,2‐a; 2′, l′‐c][1,4]diazepin werden dargestellt und gegen Trichomonas vaginalis, Entamoeba histolytica und Giardia muris getestet.
PIERO MELLONI, DOMENICO FUSAR‐BASSINI, WILLY LOGEMANN, ANGELO FORGIONE, EMANUELE DRADI, IVO DE CARNERI, ALBERTA BIANCHI, FRANCA TRANE   +7 more
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Novel Hydrophilic Riminophenazines as Potent Antiprotozoal Agents

ChemMedChem, 2019
AbstractSAR studies on a set of novel hydrophilic C‐2 aminopyridinyl riminophenazines bearing variously functionalized basic side chains at C‐3 were conducted. The novel compounds were evaluated for in vitro activity against two different species of Leishmania promastigotes, intramacrophage Leishmania amastigotes, chloroquine‐sensitive and chloroquine ...
Ivan Bassanini, Silvia Parapini, Nicoletta Basilico, Anna Sparatore   +3 more
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