Results 161 to 170 of about 5,274,206 (218)

Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents.

Current Medicinal Chemistry, 2021
BACKGROUND Parasitic diseases caused by protozoa such as Chagas disease, leishmaniasis, malaria, African trypanosomiasis, amebiasis, trichomoniasis, and giardiasis are considered serious public health problems in developing countries.
Lenci K. Vázquez-Jiménez, A. Moreno-Herrera, Alfredo Juárez-Saldivar, Alonzo González-González, Eyrá Ortiz-Pérez, Alma D. Paz-González, I. Palos-Pizarro, E. Ramírez‐Moreno, Gildardo Rivera   +8 more
semanticscholar   +1 more source

Tinidazole: A nitroimidazole antiprotozoal agent

Clinical Therapeutics, 2005
Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
openaire   +2 more sources

Chapter-05 Antiparasitic/Antiprotozoal Agents

, 2016
V. Ramesh, K. Sardana
semanticscholar   +2 more sources

Antiprotozoal Agents: An Overview

Anti-Infective Agents in Medicinal Chemistry, 2009
The therapy of parasitic diseases has relied, until recently, on the use of a very limited number of drugs, most of them of low efficacy, leading to side effects and in certain cases with high toxicity. This review focuses on the chemother- apy to treat diseases caused by Trypanosoma cruzi (Chagas' disease), Trypanosoma b.
C. Graebin, F. Uchoa, L. Bernardes, V. Campo, I. Carvalho, V. Eifler-Lima   +5 more
openaire   +1 more source

Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents.

Current Medicinal Chemistry, 2020
Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases.
A. Moreno-Herrera, Sandra Cortez-Maya, V. Bocanegra-García, B. Banik, Gildardo Rivera   +4 more
semanticscholar   +1 more source

N-Mannich bases of benzimidazole as a potent antitubercular and antiprotozoal agents: Their synthesis and computational studies

Synthetic Communications, 2020
This article dealing with the microwave assisted synthesis of N-Mannich bases of pyridine clubbed with two different benzimidazole cores with their micromolar biological potency.
V. M. Patel, N. Patel, M. Chan-Bacab, Gildardo Rivera   +3 more
semanticscholar   +1 more source

Chemistry of Antiprotozoal Agents

1986
The search for agents useful for the prevention or cure of the protozoal diseases malaria and sleeping sickness was closely linked to the early development of medicinal chemistry (see Chapter 1). Unlike antibacterial agents, for which a few chemical structural classes exhibit a wide spectrum of biological activity, antiprotozoal activity exists in a ...
John C. Chabala, Max W. Miller
openaire   +1 more source

A ChemoEnzymatic Approach for the Preparation of “Linear‐Shaped” Diaryl Pyrazines as Potential Antiprotozoal Agents

Annalen der Pharmacie
Nitrogenous heterocyclic rings are present in a wide range of drugs, natural compounds, and fine chemicals and are considered privileged scaffolds in medicinal chemistry.
I. Bassanini, Tommaso Braga, C. Tognoli, M. Vanoni, Gaia Mazza, N. Basilico, S. Parapini, Sergio Riva   +7 more
semanticscholar   +1 more source

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents

European Journal of Medicinal Chemistry, 2011
A new series of fourteen dicationic flexible triaryl bis-guanidines 3a,b, bis-N-substituted guanidines 7a,b and 8a,b as well as bis-imidamides 9-12a,b having a 1,3- or 1,4-diphenoxybenzene scaffold backbone were synthesized.
W David Wilson, Reem Arafa, Tanja Wenzler   +2 more
exaly   +2 more sources

Antiprotozoal and Anthelmintic Agents

2018
Combination chemotherapy is commonly indicated for treatment of parasitic diseases and dictated by a requirement to combine the aim of effective chemotherapy with the wish to minimize emergence of drug resistance. Throughout the past few decades, the clinical pharmacokinetics and metabolism of many antiparasitic agents have been elucidated ...
Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom   +2 more
openaire   +1 more source