Results 151 to 160 of about 5,274,206 (218)

Evaluating acridones as novel therapeutics for human babesiosis. [PDF]

Antimicrob Agents Chemother
Vydyam P, Zhang E, Pal AC, Dodean RA, Kancharla P, Kelly JX, Ben Mamoun C.   +6 more
europepmc   +1 more source

Recent Advances in the Medicinal Chemistry of Phenothiazines, New Anticancer and Antiprotozoal Agents

Current Medicinal Chemistry, 2021
BACKGROUND Molecules that have a phenothiazine scaffold have been considered versatile organic structures with a wide variety of biological activities: antipsychotic, anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, and ...
Gildardo Rivera, Alma D Paz-González, Maria Laura Bolognesi   +2 more
exaly   +3 more sources

Novel Hydrophilic Riminophenazines as Potent Antiprotozoal Agents

ChemMedChem, 2019
SAR studies on a set of novel hydrophilic C‐2 aminopyridinyl riminophenazines bearing variously functionalized basic side chains at C‐3 were conducted. The novel compounds were evaluated for in vitro activity against two different species of Leishmania ...
I. Bassanini, S. Parapini, N. Basilico, A. Sparatore   +3 more
semanticscholar   +5 more sources

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Thiazolidin-4-one-based derivatives – Efficient tools for designing antiprotozoal agents. A review of the last decade

Bioorganic Chemistry, 2023
Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical significance for medicinal chemistry. This heterocyclic ring has been reported to possess a variety of biological activities, including antiprotozoal activities ...
Nazar Trotsko, Sławomir Mandziuk, Jacek Szczepanski   +2 more
exaly   +2 more sources

Antiprotozoal agents: How have they changed over a decade?

Archiv der Pharmazie, 2021
Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low‐ or low‐to‐middle‐income countries located in tropical and subtropical zones.
Vitória de Souza Fernandes, Rafael da Rosa, L. Zimmermann, Kamilla R Rogério, A. Kümmerle, L. S. C. Bernardes, Cedric S. Graebin   +6 more
semanticscholar   +2 more sources

Antiprotozoal Agents from Plant Sources

Planta Medica, 1991
Protozoa are responsible for a number of serious tropical diseases including amoebiasis, leishmaniasis, malaria, and trypanosomiasis. New drugs are required for the treatment of these diseases and the potential of plants to produce new clinical agents is discussed.
Colin Wright, J David Phillipson, J Phillipson   +2 more
exaly   +4 more sources

Saponins as Potential Antiprotozoal Agents

Topics in Medicinal Chemistry, 2021
The sphere of natural products is an abundant source for discovery of therapeutic drugs for the treatment of neglected parasitic diseases. Various classes of chemical substances displayed antiprotozoal activity, such as alkaloids, terpenoids, saponins, and flavonoids.
A. Amaral, Aline de S. Ramos, J. L. Ferreira, M. M. D. de Almeida, Jefferson D. da Cruz, Danielle L. de Oliveira, A. Maria, A. A. de Oliveira, I. Rodrigues, J. R. de A. Silva   +9 more
semanticscholar   +2 more sources

A promising class of antiprotozoal agents, design and synthesis of novel Pyrimidine–Cinnamoyl hybrids

European Journal of Medicinal Chemistry
Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of the greatest global health crises, especially in Africa. The emergence of antimalarial drug resistance continues to be a health problem necessitating an urgent need ...
Rajshekhar Karpoormath, Vincent Obakachi, Baji Baba Shaik   +2 more
exaly   +2 more sources

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

European journal of medicinal chemistry, 2018
We discovered a series of azole antifungal compounds as effective antiprotozoal agents. They displayed promising inhibitory activities within the micromolar-submicromolar range against P. falciparum, L. donovani, and T. b. rhodesiense.
Francesco Saccoliti, V. N. Madia, Valeria Tudino, Alessandro De Leo, L. Pescatori, A. Messore, D. de Vita, L. Scipione, R. Brun, M. Kaiser, P. Mäser, C. M. Calvet, Gareth Jennings, L. Podust, R. Costi, R. Di Santo   +15 more
semanticscholar   +2 more sources

Advances in the Development of Carbonic Anhydrase Inhibitors as New Antiprotozoal Agents.

Current Medicinal Chemistry, 2023
BACKGROUND Parasitic diseases are a public health problem despite the existence of drugs for their treatment. These treatments have variable efficacy and, in some cases, serious adverse effects.
Eyrá Ortiz-Pérez, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Timoteo Delgado-Maldonado, Alonzo González González, Carlos Gaona-López, A. Moreno-Herrera, Karina Vázquez, Gildardo Rivera   +8 more
semanticscholar   +1 more source