The Potassium Channel Blocker β-Bungarotoxin from the Krait Bungarus multicinctus Venom Manifests Antiprotozoal Activity [PDF]
Biomedicines, 2023 Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression.
Alexey V. Osipov +9 more
doaj +2 more sources
Antiprotozoal Activity of Achillea ptarmica (Asteraceae) and Its Main Alkamide Constituents [PDF]
Molecules, 2014 In the course of our ongoing screening of plants of the family Asteraceae for antiprotozoal activity, a CH2Cl2-extract from the flowering aerial parts of Achillea ptarmica L.
Julia B. Althaus +3 more
doaj +4 more sources
Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives [PDF]
Molecules, 2021 Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar +9 more
doaj +2 more sources
Molecules, 2021 Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products.
Valery M. Dembitsky +4 more
doaj +3 more sources
Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis [PDF]
Veterinary World, 2023 Background and Aim: Blastocystis hominis is an intestinal protozoan in humans and animals. The parasite causes mild-to-severe intestinal complications, such as diarrhea, in healthy humans and immunocompromised hosts.
Chalermpon Kaewjai +3 more
doaj +2 more sources
Antiprotozoal Activity of Xanthone Derivatives
Orbital: The Electronic Journal of Chemistry, 2020 A series of xanthone derivatives containing different side chains, including ω-bromo and ω-aminoalkoxylxanthones (with linear alkoxy chains of 3, 4 and 5 carbon atoms and methyl, propyl, tert-butylamino and piperidinyl moieties), synthesized from the ...
Ana Camila Micheletti +5 more
doaj +4 more sources
Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach [PDF]
Scientific Reports, 2022 Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen +13 more
doaj +2 more sources
Synthesis and Antiprotozoal Activity of Azabicyclo-Nonane Pyrimidine Hybrids [PDF]
Molecules, 2022 2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness.
Clemens Hinteregger +6 more
doaj +2 more sources
ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE). [PDF]
Afr J Tradit Complement Altern Med, 2016 Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron ...
Roca-Mézquita C +8 more
europepmc +5 more sources
Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives [PDF]
Molecules, 2014 A series of 14 (E)-cinnamic N-acylhydrazone derivatives, designed through molecular hybridization between the (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)prop-2-en-1-one and (E)-3-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)-7-methoxy-2 ...
Samir Aquino Carvalho +4 more
doaj +2 more sources