Results 1 to 10 of about 113,669 (290)

Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats

Biomolecules, 2022
The ventral tegmental area (VTA) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. Although GABAA receptors and AKT-GSK3β signaling are involved in the pathophysiology of mental disorders and are modulated by ...
Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng   +3 more
doaj   +1 more source

Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model

Frontiers in Cellular Neuroscience, 2022
Introduction: Neuroinflammation in the central nervous system, particularly the prefrontal cortex (PFC), plays a role in the pathogenesis of schizophrenia, which has been found to be associated with maternal immune activation (MIA).
Yueqing Su, Yueqing Su, Yueqing Su, Yueqing Su, Jiamei Lian, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng, Chao Deng   +9 more
doaj   +1 more source

Seventy Years of Antipsychotic Development: A Critical Review

Biomedicines, 2023
Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we have only been able to improve the tolerability but not the overall efficacy of currently available APMs, as reflected by effectiveness trials in Europe and the ...
Mujeeb U. Shad
doaj   +1 more source

Comparison of Haloperidol and Quetiapine for Treatment of Delirium in Critical Illness: A Prospective Randomised Double-blind Placebo-controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Delirium is associated with an increased chance of death, prolonged hospitalisation, higher healthcare costs, and possibly long-term brain damage in survivors.
Rishabah Garg, Vipin Kumar Singh, Pratishruti, GP Singh   +3 more
doaj   +1 more source

Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers

Frontiers in Pain Research, 2022
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ...
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Megan E. Curtis, Angela M. Boley, Maxim Eckmann   +8 more
doaj   +1 more source

A study on the effect of COVID-19 infection on the serum concentration of antipsychotic drugs. [PDF]

BMC Psychiatry
Liu T, Shi Z, Chen R, Zhang H, Wang C, Gao W, Gao P, Li W.   +7 more
europepmc   +3 more sources

Maintenance Therapy of Psychosis Spectrum Disorders in a Real-World Setting: Antipsychotics Prescription Patterns and Long-Term Benzodiazepine Use

Frontiers in Psychiatry, 2022
BackgroundMaintenance therapy of patients with primary psychosis spectrum disorders (PSD) in the Western Balkans has received limited interest so far.
Nadja P. Maric, Sanja Andric Petrovic, Manuela Russo, Stefan Jerotic, Ivan Ristic, Bojana Savić, Tamara Pemovska, Milos Milutinovic, Emina Ribic, Silvana Markovska-Simoska, Alma Dzubur Kulenovic, Nikolina Jovanovic   +11 more
doaj   +1 more source

Pharmacogenetics of Antipsychotics [PDF]

The Canadian Journal of Psychiatry, 2014
Objective: During the past decades, increasing efforts have been invested in studies to unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response, and occurrence of adverse effects. These studies aimed to improve clinical care by predicting outcome of treatment with APs and thus allowing for individualized treatment ...
Eva J, Brandl, James L, Kennedy, Daniel J, Müller   +2 more
openaire   +2 more sources

Antipsychotics and Amotivation [PDF]

Neuropsychopharmacology, 2015
Antipsychotic drugs are thought to produce secondary negative symptoms, which can also exacerbate primary negative symptoms. In the present study, we examined whether motivational deficits in particular were related to antipsychotic treatment in patients with schizophrenia in a dose-dependent manner.
Gagan, Fervaha, Hiroyoshi, Takeuchi, Jimmy, Lee, George, Foussias, Paul J, Fletcher, Ofer, Agid, Gary, Remington   +6 more
openaire   +2 more sources

The diagnostic dilemma in a patient with neuroleptic malignant syndrome during the COVID‐19 pandemic: A significant increase in acute phase reactants

Clinical Case Reports, 2023
Key Clinical Message In some patients, neuroleptic malignant syndrome is accompanied significant high levels of erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP).
Forouzan Elyasi, Mehran Zarghami, Arghavan Fariborzifar, Hamed Cheraghmakani, Mahboobeh Shirzad, Feteme Kazempour   +5 more
doaj   +1 more source