Results 1 to 10 of about 181,112 (317)

Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats

Biomolecules, 2022
The ventral tegmental area (VTA) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. Although GABAA receptors and AKT-GSK3β signaling are involved in the pathophysiology of mental disorders and are modulated by ...
Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng   +3 more
doaj   +1 more source

Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model

Frontiers in Cellular Neuroscience, 2022
Introduction: Neuroinflammation in the central nervous system, particularly the prefrontal cortex (PFC), plays a role in the pathogenesis of schizophrenia, which has been found to be associated with maternal immune activation (MIA).
Yueqing Su, Yueqing Su, Yueqing Su, Yueqing Su, Jiamei Lian, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng, Chao Deng   +9 more
doaj   +1 more source

20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)

World Psychiatry, 2020
Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long‐term use is harmful for patients’ physical well‐being. However, there are no long‐term studies which have verified this view.
H. Taipale, A. Tanskanen, J. Mehtälä, P. Vattulainen, C. Correll, J. Tiihonen   +5 more
semanticscholar   +1 more source

Efficacy of metformin for treatment and prevention of antipsychotic-induced overweight and obesity in women: an open-label, randomized, prospective placebo-controlled study

Ожирение и метаболизм, 2021
Background: The prevalence of obesity and metabolic abnormalities is increased patients with mental disorders receiving psychopharmacotherapy, which significantly impairs their treatment adherence.Aims: To evaluate the efficacy and safety of metformin in
O. A. Yunilaynen, I. V. Oleichik, S. V. Sizov, P. A. Baranov, E. G. Starostina   +4 more
doaj   +1 more source

Dreams, Sleep, and Psychotropic Drugs

Frontiers in Neurology, 2020
Over the past 60 years, the impact of psychotropic drugs on dream recall and content has been scarcely explored. A review of the few existing experimental results on the topic leads us to the following conclusions.
Alain Nicolas, Perrine M. Ruby
doaj   +1 more source

Acute olanzapine toxicity in a toddler

Open Journal of Psychiatry and Allied Sciences, 2020
Olanzapine is an antipsychotic medication, which is approved for treatment of psychiatric illnesses among various age groups of psychiatric patients. Accidental consumption of olanzapine is uncommon among the paediatric age group.
Hemendra Singh, Sahana Amarnath Boggaram, Mamatha Krishna Murthy, ATK Rau   +3 more
doaj   +1 more source

Risperidone response in patients with schizophrenia drives DNA methylation changes in immune and neuronal systems [PDF]

, 2023
Background: The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens of the disease call for faster alternatives. Material \& methods: In a search for predictive biomarkers of antipsychotic response, blood methylomes of 28 patients were analyzed before ...
arxiv   +1 more source

Real-World Functioning in Patients With Schizophrenia: Beyond Negative and Cognitive Symptoms

Frontiers in Psychiatry, 2021
Introduction: Interest in the idea of recovery for certain patients with schizophrenia has been growing over the last decade. Improving symptomatology and functioning is crucial for achieving this.
María Paz García-Portilla, María Paz García-Portilla, María Paz García-Portilla, María Paz García-Portilla, María Paz García-Portilla, Leticia García-Álvarez, Leticia García-Álvarez, Leticia García-Álvarez, Leticia García-Álvarez, Leticia García-Álvarez, Leticia González-Blanco, Leticia González-Blanco, Leticia González-Blanco, Leticia González-Blanco, Leticia González-Blanco, Francesco Dal Santo, Francesco Dal Santo, Francesco Dal Santo, Francesco Dal Santo, Teresa Bobes-Bascarán, Teresa Bobes-Bascarán, Teresa Bobes-Bascarán, Teresa Bobes-Bascarán, Teresa Bobes-Bascarán, Clara Martínez-Cao, Clara Martínez-Cao, Clara Martínez-Cao, Ainoa García-Fernández, Ainoa García-Fernández, Ainoa García-Fernández, Pilar A. Sáiz, Pilar A. Sáiz, Pilar A. Sáiz, Pilar A. Sáiz, Pilar A. Sáiz, Julio Bobes, Julio Bobes, Julio Bobes, Julio Bobes, Julio Bobes   +39 more
doaj   +1 more source

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

New England Journal of Medicine, 2005
BACKGROUND The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly.
J. Lieberman, T. Stroup, J. McEvoy, J. McEvoy, M. Swartz, R. Rosenheck, D. Perkins, R. Keefe, S. Davis, C. E. Davis, B. Lebowitz, J. Severe, J. Hsiao   +12 more
semanticscholar   +1 more source

Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Background Stroke/thromboembolic events, infections, and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify
Yasaman Malekizadeh, Gareth Williams, Mark Kelson, David Whitfield, Jonathan Mill, David A. Collier, Clive Ballard, Aaron R. Jeffries, Byron Creese   +8 more
doaj   +1 more source