Results 151 to 160 of about 31,897 (204)
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Clozapine: A Novel Antipsychotic Agent
DICP, 1989Clozapine is an antipsychotic without the extrapyramidal adverse effects associated with currently marketed antipsychotics. In animals, this drug has not been shown to induce catalepsy and only weakly antagonizes the stereotypic movements induced by apomorphine and the amphetamines.
Richard L. Wagner +2 more
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New England Journal of Medicine, 1991
This review considers the discovery of clozapine; its chemistry, pharmacologic activities, metabolism, and pharmacokinetics; evidence of its efficacy; and its side effects and appropriate clinical ...
John A. Oates +3 more
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This review considers the discovery of clozapine; its chemistry, pharmacologic activities, metabolism, and pharmacokinetics; evidence of its efficacy; and its side effects and appropriate clinical ...
John A. Oates +3 more
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Antipsychotic to anticancer agent?
Nature Reviews Cancer, 2012A new study shows that a clinically approved drug might selectively target cancer stem cells for differentiation.
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Toxicology of Antipsychotic Agents
1980The introduction of chlorpromazine and reserpine for psychiatric use has been followed by a steady increase in the number of psychotropic agents. In the development of new compounds, there have been many attempts to improve the therapeutic indices and to vary the profile of pharmacodynamic activity in accordance with clinical requirements.
F. Leuschner, R. Hempel, W. Neumann
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Atypical antipsychotic agents: A critical review
American Journal of Health-System Pharmacy, 2000The pharmacology, efficacy, and adverse effects of atypical antipsychotic agents when used to treat schizophrenia and other disorders are reviewed. Atypical antipsychotic agents were developed in response to problems with typical agents, including lack of efficacy in some patients, lack of improvement in negative symptoms, and troublesome adverse ...
Jodi A. Worrel +3 more
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Neurosyphilis, Malaria, and the Discovery of Antipsychotic Agents
Harvard Review of Psychiatry, 2008Four of the most disabling human diseases are syphilis, malaria, schizophrenia, and manic-depressive illness. The history of the development of treatments for these seemingly unrelated disorders intersects at several points. Treatment of tertiary cerebral syphilis (general paresis) by inducing fever with malaria led to a Nobel Prize.
Frances R. Frankenburg +1 more
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Chapter 1. Antipsychotic Agents
1988Publisher Summary The emerging technologies of functional and anatomical brain imaging are finding more frequent application in the study of brain structural abnormalities that may underlie the etiology of schizophrenia. New insight into the role of the regional distribution and receptor binding of anti-psychotic agents has been brought by ...
Katherine S. Takaki, J. S. New
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ARE BENZODIAZEPINES ANTIPSYCHOTIC AGENTS ? [PDF]
The Lancet, 1975 Gabriella Ba, Marco Trabucchi
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Piperazinylalkyl Heterocycles as Potential Antipsychotic Agents
Journal of Medicinal Chemistry, 1995We recently reported on a series of pyrrole Mannich bases orally active in inhibiting the conditioned avoidance response (CAR) in rats. These compounds exhibit affinity for both D2 and 5-HT1A receptors, and some are noncataleptogenic. Such a profile suggests that they may be potential antipsychotic agents which lack the propensity for causing ...
Kukla Mj +9 more
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Basic Principles in the Use of Antipsychotic Agents
Psychiatric Services, 1973After 17 years of extensive USC in treating the psychoses, antipsychotic agents are still inappropriately prescribed by psychiatrists and other physicians. To help remedy the situation, the author has compiled a set of clearly defined principles of drug administration.
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