Results 61 to 70 of about 3,281,120 (365)

Productivity of key informants for identifying blind children: evidence from a pilot study in Malawi.

, 2009
OBJECTIVES: To determine the productivity of village-based 'key informants' (KIs) in identifying blind children. MATERIALS AND METHODS: Ngabu subdistrict (population 101,000) of Chikwawa district was divided into KI catchment areas.
Courtright, P, Kalua, K, Muhit, M, Patel, D   +3 more
core   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

The association between antipsychotic agents and the risk of myocardial infarction: a systematic review

British Journal of Clinical Pharmacology, 2011
AIM Patient populations that are prescribed antipsychotic agents have higher cardiovascular mortality rates. The risk of myocardial infarction is influenced by various factors that are more prevalent in patients with a mental illness.
R. Brauer, I. Douglas, L. Smeeth
semanticscholar   +1 more source

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase‐IIa Randomized, Double‐Blind, Sham‐Controlled Feasibility Study

Autism Research, EarlyView.
ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham‐controlled, double‐blind parallel‐group Phase‐
Christina Luckhardt, Magdalena Schütz, Andreas M. Mühlherr, Sara Boxhoorn, Christine Ecker, Hanna Mössinger, Julia Siemann, Fabienne Schlechter, Miguel Castelo‐Branco, Helena C. Pereira, Marianne Latinus, Camille Ricou, Frederique Bonnet‐Brilhault, Ricardo Salvador, Giulio Ruffini, Rafal Nowak, Michael Siniatchkin, Astrid Dempfle, Christine M. Freitag   +18 more
wiley   +1 more source

Atypical antipsychotic therapy in Parkinson's disease psychosis: A retrospective study. [PDF]

, 2017
ObjectiveParkinson's disease psychosis (PDP) is a frequent complication of idiopathic Parkinson's disease (iPD) with significant impact on quality of life and association with poorer outcomes.
Bizzarri, Cummings, Fernandez, Fernandez, Fénelon, Gama, Goldman, Hack, Hubbard, Kiferle, Lertxundi, McFarland, Meltzer, Meral, Mesquita, Mocci, Munhoz, Noel, Pagonabarraga, Prohorov, Rabey, Reichmann, Rolland, Seppi, Shotbolt, Starkstein, Thomas, Vanover, Weintraub, Zhu   +29 more
core   +2 more sources

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Frontiers in Cellular and Infection Microbiology, 2023
ObjectiveAtypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children with ...
Shao-rui Hao, Yuan-yue Zhou, Yuan-yue Zhou, Xue Zhang, Xue Zhang, Hai-yin Jiang   +5 more
doaj   +1 more source

The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. [PDF]

, 2009
Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including ...
Feifel, D, Goldenberg, Joseph R, Liu, Philip YT, Melendez, Gilia, Mexal, S, Shilling, Paul D   +5 more
core   +2 more sources

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen, Signe Wegmann Düring, Gesche Jürgens   +2 more
wiley   +1 more source

Neuroleptic malignant syndrome

Journal of Family Medicine and Primary Care, 2016
Neuroleptic malignant syndrome (NMS) is a life-threatening emergency that is often seen as a complication of antipsychotic agents. It is characterized by a tetrad of motor, behavioral, autonomic, and laboratory abnormalities.
Bino Rajamani, Yashwant Kumar, Sajitha M.F. Rahman   +2 more
doaj   +1 more source