Results 61 to 70 of about 56,519 (290)

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Psychotic Disorders: Self-Directed Learning Module

MedEdPORTAL, 2014
Introduction Psychotic disorders, including schizophrenia, are listed among the ADMSEP Clinical Learning Objectives for Psychiatry Education of Medical Students (2007) and lead to significant morbidity, mortality, and healthcare burden for the patient ...
Sarah Johnson, Adriana Foster, Joyce Spurgeon, Chelsea Neumann   +3 more
doaj   +1 more source

Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes. [PDF]

, 2017
IntroductionThere are currently no guidelines for switching patients from oral risperidone to paliperidone palmitate (Invega Sustenna®). Furthermore, the paliperidone long-acting injectable (LAI) package insert does not recommend bridging with oral ...
Hsia, Stephanie L, Jackson, Elizabeth, Lacro, Jonathan P, Leckband, Susan G, Rao, Sanjai   +4 more
core   +2 more sources

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source

Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]

, 2002
Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Amann, B., Dittmann, Sandra, Forsthoff, A., Grunze, Heinz, Hummel, B., Matzner, N.   +5 more
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Practical Guidance for the Use of Long-Acting Injectable Antipsychotics in the Treatment of Schizophrenia

Psychology Research and Behavior Management, 2022
Ilaria Riboldi,1 Daniele Cavaleri,1 Chiara A Capogrosso,1 Cristina Crocamo,1 Francesco Bartoli,1 Giuseppe Carrà1,2 1Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 2Division of Psychiatry, University College London, London,
Riboldi I, Cavaleri D, Capogrosso CA, Crocamo C, Bartoli F, Carrà G   +5 more
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Metoclopramide Neurological Side Effects Screening; A Pharmacovigilence Study in Romanian Community Pharmacies [PDF]

, 2015
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics.
Junghină, Adrian, Mireșan, Horațiu, Pleșu, Mihaela, Scutari, Corina, Ștefănescu, Emil   +4 more
core   +4 more sources

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression

Drug Design, Development and Therapy, 2016
Dawn Bruijnzeel, Rajiv Tandon Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA Abstract: Antipsychotic agents, utilized for the treatment of a range of psychiatric disorders, differ substantially in terms of ...
Bruijnzeel D, Tandon R
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