Results 181 to 190 of about 132,795 (279)

Pharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates. [PDF]

open access: yesPharmaceutics, 2022
Gelé T   +7 more
europepmc   +1 more source

Altered Cytokine‐Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine‐Non‐Responsiveness in Aging and HIV

open access: yesAging Cell, Volume 25, Issue 3, March 2026.
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Sheldon Davis   +4 more
wiley   +1 more source

HIV-1 cell-to-cell infection of macrophages escapes type I interferon and host restriction factors, and is resistant to antiretroviral drugs. [PDF]

open access: yesPLoS Pathog
Woottum M   +9 more
europepmc   +1 more source

Substance Use and Sex Index version 2 (SUSI‐2): Validation of a brief questionnaire for the measurement of behaviours associated with transmission of blood borne viruses and sexually transmitted infections

open access: yesAddiction, Volume 121, Issue 3, Page 670-679, March 2026.
Abstract Aims This study sought to validate a community‐acceptable Substance Use & Sex Index (SUSI) for use in substance use intervention research. SUSI aims to measure behaviours associated with the transmission of blood‐borne viruses (BBV) and sexually transmitted infections (STI) among people who use substances and incorporate contemporary sexual ...
Brendan Clifford   +9 more
wiley   +1 more source

Evaluation of Drug–Drug Interaction Potential Between the Oral Antibiotic Zoliflodacin and the CYP3A4 Inhibitor Itraconazole: A Phase 1 Study in Healthy Participants

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Zoliflodacin is a first‐in‐class oral spiropyrimidinetrione antibiotic being developed for patients with uncomplicated gonorrhea, including those infected with multidrug‐resistant strains. Because zoliflodacin is metabolized by cytochrome P450 3A4 (CYP3A4), concomitant administration with a CYP3A inhibitor has the potential to increase ...
Alison Luckey   +10 more
wiley   +1 more source

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