Results 111 to 120 of about 141,326 (319)

Nonparametric Methodology for the Time-Dependent Partial Area under the ROC Curve [PDF]

arXiv, 2011
To assess the classification accuracy of a continuous diagnostic result, the receiver operating characteristic (ROC) curve is commonly used in applications. The partial area under the ROC curve (pAUC) is one of widely accepted summary measures due to its generality and ease of probability interpretation. In the field of life science, a direct extension
arxiv  

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Description of the EMOD-HIV Model v0.7 [PDF]

arXiv, 2012
The expansion of tools against HIV transmission has brought increased interest in epidemiological models that can predict the impact of these interventions. The EMOD-HIV model was recently compared to eleven other independently developed mathematical models of HIV transmission to determine the extent to which they agree about the potential impact of ...
arxiv  

Inference about ATE from Observational Studies with Continuous Outcome and Unmeasured Confounding [PDF]

arXiv, 2013
For settings with a binary treatment and a binary outcome, instrumental variables can be used to construct bounds on a causal treatment effect. With continuous outcomes, meaningful bounds are more difficult to obtain because the domain of the outcome is typically unrestricted.
arxiv  

Managing discordance between HbA1c and glucose management indicator

Diabetic Medicine, EarlyView.
Abstract Aims The assessment of haemoglobin A1c (HbA1c) continues to play an essential role in diabetes care; however, major advances in new technologies widen the armament available to clinicians to further refine treatment for their patients. Whilst HbA1c remains a critical glycaemic marker, advances in technologies such as Continuous Glucose ...
Erna Lenters‐Westra, Marion Fokkert, Eric S. Kilpatrick, Erwin Schleicher, Scott Pilla, Emma English, Peter van Dijk   +6 more
wiley   +1 more source

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age

Brazilian Journal of Infectious Diseases, 2014
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately ...
Thiago Silva Torres, Sandra Wagner Cardoso, Luciane S. Velasque, Valdilea G. Veloso, Beatriz Grinsztejn   +4 more
doaj  

Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models

The Lancet Global Health, 2014
Background: New WHO guidelines recommend initiation of antiretroviral therapy for HIV-positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was previously recommended.
Jeffrey W Eaton, PhD, Nicolas A Menzies, MPH, John Stover, MA, Valentina Cambiano, MS, Leonid Chindelevitch, PhD, Anne Cori, PhD, Jan A C Hontelez, PhD, Salal Humair, PhD, Cliff C Kerr, PhD, Daniel J Klein, PhD, Sharmistha Mishra, MD, Kate M Mitchell, PhD, Brooke E Nichols, MS, Prof. Peter Vickerman, DPhil, Roel Bakker, PhD, Till Bärnighausen, DSc, Anna Bershteyn, PhD, Prof. David E Bloom, PhD, Marie-Claude Boily, PhD, Stewart T Chang, PhD, Ted Cohen, DPH, Peter J Dodd, PhD, Prof. Christophe Fraser, PhD, Chaitra Gopalappa, PhD, Prof. Jens Lundgren, DMSc, Natasha K Martin, DPhil, Evelinn Mikkelsen, MSc, Elisa Mountain, MSc, Quang D Pham, MD, Michael Pickles, PhD, Prof. Andrew Phillips, PhD, Lucy Platt, PhD, Carel Pretorius, PhD, Holly J Prudden, MSc, Prof. Joshua A Salomon, PhD, David A M C van de Vijver, PhD, Sake J de Vlas, PhD, Bradley G Wagner, PhD, Richard G White, PhD, David P Wilson, PhD, Lei Zhang, PhD, John Blandford, PhD, Gesine Meyer-Rath, PhD, Michelle Remme, MSc, Paul Revill, PhD, Nalinee Sangrujee, PhD, Fern Terris-Prestholt, PhD, Meg Doherty, PhD, Nathan Shaffer, MD, Prof. Philippa J Easterbrook, MD, Gottfried Hirnschall, MD, Prof. Timothy B Hallett, PhD   +51 more
doaj   +1 more source

Dual Qualitative-Quantitative Nested PCR for Detection of JC Virus in Cerebrospinal Fluid: High Potential for Evaluation and Monitoring of Progressive Multifocal Leukoencephalopathy in AIDS Patients Receiving Highly Active Antiretroviral Therapy [PDF]

, 1999
Darı́o Garcı́a de Viedma, Roberto Alonso, Pilar Miralles, Juan Berenguer, Marta Rodríguez‐Créixems, Emilio Bouza   +5 more
openalex   +1 more source

Functional T Cell Reconstitution and Human Immunodeficiency Virus–1–Specific Cell‐Mediated Immunity during Highly Active Antiretroviral Therapy [PDF]

, 1999
Oscar Pontesilli, Susana R. Kerkhof‐Garde, Daan W. Notermans, Norbert A. Foudraine, Marijke Roos, Michèl R. Klein, Sven A. Danner, Joep M. A. Lange, Frank Miedema   +8 more
openalex   +1 more source

Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.

PLoS ONE, 2015
ObjectiveLimited data are available from the developing world on antiretroviral drug resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy, especially in the context of a high tuberculosis burden.
Theresa M Rossouw, Ute D Feucht, George Melikian, Gisela van Dyk, Winifred Thomas, Nicolette M du Plessis, Theunis Avenant   +6 more
doaj   +1 more source