Results 61 to 70 of about 4,692,840 (382)

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Antiretroviral therapy in children

Southern African Journal of HIV Medicine, 2000
No abstract available.
openaire   +7 more sources

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Improving antiretroviral therapy adherence in resource‐limited settings at scale: a discussion of interventions and recommendations

Journal of the International AIDS Society, 2017
Introduction: Successful population‐level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scale‐up and, ultimately, the end of AIDS.
J. Haberer, L. Sabin, K. R. Amico, C. Orrell, O. Galárraga, A. Tsai, R. Vreeman, I. Wilson, N. Sam-Agudu, T. Blaschke, B. Vrijens, C. Mellins, R. Remien, S. Weiser, E. Lowenthal, M. Stirratt, P. Sow, B. Thomas, N. Ford, E. Mills, R. Lester, J. Nachega, B. Bwana, F. Ssewamala, L. Mbuagbaw, P. Munderi, E. Geng, D. Bangsberg   +27 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study

SAGE Open Medicine
Objectives: Optimal adherence to antiretroviral therapy is required for viral load suppression. This study investigated the sociodemographic (age, sex, marital status, level of education, monthly income, settlement type, distance to the antiretroviral ...
Elvis Enowbeyang Tarkang, Emmanuel Manu, Fortress Yayra Aku, Judith Anaman-Torgbor, Nelisiwe Khuzwayo   +4 more
doaj   +1 more source

CD4 LYMPHOCYTE IN HIV / AIDS BEFORE AND AFTER ANTIRETROVIRAL THERAPY

Berkala Kedokteran, 2017
: Human Immunodefficiency Virus (HIV) is a virus that decreases the human immunity system, therefore the infected people become susceptible to any kind of infections.
Rangsang Bagus Prabowo, Dewi Indah Noviana Pertiwi, FX. Hendriyono   +2 more
doaj   +1 more source

Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis

Clinical Infectious Diseases, 2016
This meta-analysis provides strong evidence that antiretroviral therapy (ART) has led to a major reduction in the incidence of key opportunistic infections (OIs) in low- and middle-income countries. ART was estimated to have averted about a million cases
A. Low, Georgios Gavriilidis, N. Larke, M. B-Lajoie, Olivier Drouin, J. Stover, L. Muhe, P. Easterbrook   +7 more
semanticscholar   +1 more source

Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: a cohort analysis of time patterns, sex, and other risk factors. [PDF]

, 2013
BackgroundModifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects.
Begovac, Josip, Haque, Najm S, Perović Mihanović, Marta, Rutherford, George W, Zekan, Šime   +4 more
core   +1 more source