Results 71 to 80 of about 4,692,840 (382)

The cost of antiretroviral therapy in Haiti [PDF]

Cost Effectiveness and Resource Allocation, 2008
We determined direct medical costs, overhead costs, societal costs, and personnel requirements for the provision of antiretroviral therapy (ART) to patients with AIDS in Haiti.We examined data from 218 treatment-naïve adults who were consecutively initiated on ART at the GHESKIO Center in Port-au-Prince, Haiti between December 23, 2003 and May 20, 2004
Daniel W. Fitzgerald, Patrice Severe, Bruce R. Schackman, Jean W. Pape, Paul Leger, Sidney Atwood, Cynthia Riviere, Serena P. Koenig   +7 more
openaire   +4 more sources

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. [PDF]

PLoS Pathogens, 2007
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection.
Frank Maldarelli, Sarah Palmer, Martin S King, Ann Wiegand, Michael A Polis, JoAnn Mican, Joseph A Kovacs, Richard T Davey, Diane Rock-Kress, Robin Dewar, Shuying Liu, Julia A Metcalf, Catherine Rehm, Scott C Brun, George J Hanna, Dale J Kempf, John M Coffin, John W Mellors   +17 more
doaj   +1 more source

Adherence to Antiretroviral Therapy During and After Pregnancy: Cohort Study on Women Receiving Care in Malawi's Option B+ Program

Clinical Infectious Diseases, 2016
One-third of women enrolled in Malawi's program to prevent human immunodeficiency virus mother-to-child-transmission (Option B+) adhered inadequately to antiretroviral therapy during pregnancy and breastfeeding.
A. Haas, Malango T. Msukwa, M. Egger, L. Tenthani, H. Tweya, A. Jahn, O. Gadabu, K. Tal, L. Salazar-Vizcaya, Janne Estill, A. Spoerri, Nozgechi Phiri, F. Chimbwandira, J. V. van Oosterhout, O. Keiser   +14 more
semanticscholar   +1 more source

Biomarker reveals HIV's hidden reservoir. [PDF]

, 2014
Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV ...
Cockerham, Leslie R, Deeks, Steven G
core   +2 more sources

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Lau CY, Lyndaker A, Shah S, Wakim P, Mitchell A, Monroe C, Kim A, Cropper TL, Nair G, Snow J, Smith BR, Nath A, Hammoud DA.   +12 more
europepmc   +2 more sources

Adherence to Antiretroviral Therapy and Virologic Failure

Medicine, 2016
The often cited need to achieve ≥95% (nearly perfect) adherence to antiretroviral therapy (ART) for successful virologic outcomes in HIV may present a barrier to initiation of therapy in the early stages of HIV.This meta-analysis synthesized 43 studies ...
Woldesellassie M. Bezabhe, L. Chalmers, L. Bereznicki, G. Peterson   +3 more
semanticscholar   +1 more source

Challenge and co-operation: civil society activism for access to HIV treatment in Thailand. [PDF]

, 2009
Civil society has been a driving force behind efforts to increase access to treatment in Thailand. A focus on HIV medicines brought civil society and non-governmental and government actors together to fight for a single cause, creating a platform for ...
Ainsworth, Bamber, Cawthorne, Ford, Ford, Gilson, Hongthong, International Labour Organisation, Kiatying-Angsulee, Kreudhutha, Kumphitak, Kunaratanapruk, Limpananont, Lyttleton, Ministry of Public Health, Nitayarumphong, Over, Phanuphak, Pramualratana, Revenga, Rojanapithayakorn, Supakakunti, Tantivess, Towse, UNAIDS, United Nations Development Programme, Uppakaew, Walt, Wibulpolprasert, Wilson, World Bank   +30 more
core   +2 more sources

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source