Results 11 to 20 of about 45,133 (250)

Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]

, 2008
Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez, Mansoor, Moizza, Moizza Mansoor, Melendez, Alirio J.   +3 more
core   +8 more sources

Introduction of an RNA stability element at the 5 '-end of an antisense RNA cassette increases the inhibition of target RNA translation

, 2001
This communication describes improvement strategies used on a previously described two-unit antisense RNA cassette system. This cassette system encodes RNA with noncontiguous regions of complementarity to a bacterial target RNA, lad mRNA, One of the ...
Wagner, EGH, Engdahl, HM,, Lindell, M
core   +9 more sources

Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues [PDF]

, 2009
Background: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases.
Oliver, G.R., Kendrick, H., Jat, P., Oliver, Gavin, Neville, A.M., Gavin R Oliver, Howard Kendrick, Tanney, Austin, Tanney, A., Grigoriadis, A., Grigoriadis, Anita, Smalley, M.J., Austin Tanney, Anita Grigoriadis, Kendrick, Howard, Jat, Parmjit, Matt J Smalley, A Munro Neville, Neville, A. Munro, Parmjit Jat, Smalley, Matthew John   +20 more
core   +1 more source

Genetic Modification of KNAT7 Transcription Factor Expression Enhances Saccharification and Reduces Recalcitrance of Woody Biomass in Poplars

Frontiers in Plant Science, 2021
The precise role of KNAT7 transcription factors (TFs) in regulating secondary cell wall (SCW) biosynthesis in poplars has remained unknown, while our understanding of KNAT7 functions in other plants is continuously evolving.
Yogesh Kumar Ahlawat, Yogesh Kumar Ahlawat, Akula Nookaraju, Anne E. Harman-Ware, Crissa Doeppke, Ajaya K. Biswal, Ajaya K. Biswal, Chandrashekhar P. Joshi   +7 more
doaj   +1 more source

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

Journal of Lipid Research, 2005
High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL, are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholesterol ...
Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Seonjoon Koo, Ranjan J. Perera   +5 more
doaj   +1 more source

Antisense-AluSx

, 2021
Nucleotide sequences of antisense AluSx in our ...
Mina Nakama (9933231)
core   +1 more source

Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr-/- mice

Journal of Lipid Research, 2013
Due to their ability to promote positive effects across all of the lipoprotein classes, cholesteryl ester transfer protein (CETP) inhibitors are currently being developed as therapeutic agents for cardiovascular disease.
Thomas A. Bell, III, Mark J. Graham, Richard G. Lee, Adam E. Mullick, Wuxia Fu, Dan Norris, Rosanne M. Crooke   +6 more
doaj   +1 more source

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

Journal of Lipid Research, 2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism.
Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Amuthakannan Subramaniam, Brett P. Monia, Stanley T. Crooke, Rosanne M. Crooke   +6 more
doaj   +1 more source

Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides

Molecular Therapy: Nucleic Acids, 2018
Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools.
Shiyu Wang, Nickolas Allen, Xue-hai Liang, Stanley T. Crooke   +3 more
doaj   +1 more source

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

Journal for ImmunoTherapy of Cancer, 2018
Background The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune
Matthew J. Reilley, Patricia McCoon, Carl Cook, Paul Lyne, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, John Nemunaitis, Nathan Fowler, Michael Curran, Qinying Liu, Tianyuan Zhou, Joanna Schmidt, Minji Jo, Samantha J. Lee, Mason Yamashita, Steven G. Hughes, Luis Fayad, Sarina Piha-Paul, Murali V. P. Nadella, Xiaokun Xiao, Jeff Hsu, Alexey Revenko, Brett P. Monia, A. Robert MacLeod, David S. Hong   +26 more
doaj   +1 more source