Results 31 to 40 of about 45,133 (250)
Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture [PDF]
, 1999 Due to their mode of action, ribozymes show antisense effects in addition to their specific cleavage activity. In the present study we investigated whether a hammerhead ribozyme is capable of cleaving mutated Ki-ras mRNA in a pancreatic carcinoma cell ...
Piiper, Albrecht +3 more
core +1 more source
THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES AGAINST CANCER: HURDLING TO THE CLINIC
Frontiers in Chemistry, 2014 Under clinical development since the early 90’s and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics have not yet delivered a clinical drug to the market in the cancer field.
Pedro Miguel Duarte Moreno +3 more
doaj +1 more source
Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review
Biomedicines, 2021 Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and
Susanne N. Wijesinghe +2 more
doaj +1 more source
Zoonotic Diseases, 2023 Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro.
Bin Yan +4 more
doaj +1 more source
Innovative developments and emerging technologies in RNA therapeutics
RNA Biology, 2022 RNA-based therapeutics are emerging as a powerful platform for the treatment of multiple diseases. Currently, the two main categories of nucleic acid therapeutics, antisense oligonucleotides and small interfering RNAs (siRNAs), achieve their therapeutic ...
François Halloy +10 more
doaj +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Prydz, Hans +3 more
core +1 more source
Molecular Systems Biology, 2011 Strand‐specific RNA sequencing of S. pombe revealed a highly structured programme of ncRNA expression at over 600 loci. Waves of antisense transcription accompanied sexual differentiation.
Danny A Bitton +9 more
doaj +1 more source
The antisense leitmotif: A prelude [PDF]
Plasmid, 2015 Communicated by Prof.
Garcillán-Barcia, M. Pilar +1 more
openaire +3 more sources
(Non)translational medicine: RNA-based therapeutics in bacteria
Frontiers in Genetics, 2013 The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful.
Adam M Dinan, Brendan J Loftus
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source