Results 31 to 40 of about 378,124 (311)
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]
, 2014 An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M +19 more
core +1 more source
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources
The antisense leitmotif: A prelude [PDF]
Plasmid, 2015 Communicated by Prof.
Garcillán-Barcia, M. Pilar +1 more
openaire +3 more sources
The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides
Pharmaceuticals, 2022 Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve ...
Miklós Bege, Anikó Borbás
doaj +1 more source
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins [PDF]
Diabetes & Metabolism Journal, 2022 Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains.
Kyuho Kim +2 more
doaj +1 more source
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro [PDF]
, 2013 BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response.
Browne, JA +13 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2001 The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in preventing cancer cells from undergoing apoptosis. However, the function of individual Akt isoforms in the tumorigenicity of cancer cells is still not well defined.
Xuesong Liu +7 more
doaj +1 more source
THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES AGAINST CANCER: HURDLING TO THE CLINIC
Frontiers in Chemistry, 2014 Under clinical development since the early 90’s and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics have not yet delivered a clinical drug to the market in the cancer field.
Pedro Miguel Duarte Moreno +3 more
doaj +1 more source
Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review
Biomedicines, 2021 Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and
Susanne N. Wijesinghe +2 more
doaj +1 more source